Reactome | MET activates PI3K/AKT signaling

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MET activates PI3K/AKT signaling Show undefined attributes

created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10828031
displayName	MET activates PI3K/AKT signaling
eventOf	[Pathway:R-GGA-6806834] Signaling by MET - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-GGA-8851908] Activated MET binds GAB1 - Gallus gallus [Reaction:R-GGA-8851919] Activated MET binds GAB1 and GRB2 - Gallus gallus [Reaction:R-GGA-8851933] MET phosphorylates GAB1 - Gallus gallus [Reaction:R-GGA-8851954] Phosphorylated GAB1 recruits PI3K to MET - Gallus gallus [Reaction:R-GGA-8852019] MET bound PI3K generates PIP3 - Gallus gallus
inferredFrom	[Pathway:R-HSA-8851907] MET activates PI3K/AKT signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	MET activates PI3K/AKT signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49591] Gallus gallus
stId	R-GGA-8851907
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-6806834] Signaling by MET
(inferredTo)	[Pathway:R-HSA-8851907] MET activates PI3K/AKT signaling

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