Reactome | MET activates RAS signaling

Schema > Pathway > Entries

created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10995727
displayName	MET activates RAS signaling
eventOf	[Pathway:R-CEL-6806834] Signaling by MET - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-CEL-8851827] RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 - Caenorhabditis elegans
inferredFrom	[Pathway:R-HSA-8851805] MET activates RAS signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	MET activates RAS signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-8851805
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-CEL-6806834] Signaling by MET
(inferredTo)	[Pathway:R-HSA-8851805] MET activates RAS signaling

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