Reactome | MET activates RAS signaling

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MET activates RAS signaling Show undefined attributes

created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10558543
displayName	MET activates RAS signaling
eventOf	[Pathway:R-SSC-6806834] Signaling by MET - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-SSC-8851804] Activated MET recruits GRB2-1:SOS1 - Sus scrofa [Reaction:R-SSC-8851827] RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 - Sus scrofa [Reaction:R-SSC-8851842] MUC20 binds MET and inhibits GRB2 binding - Sus scrofa [Reaction:R-SSC-8851859] Activated MET binds RANBP9 and SOS1 - Sus scrofa [Reaction:R-SSC-8851877] RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET - Sus scrofa [Reaction:R-SSC-8851866] MET binds RANBP10 - Sus scrofa [Reaction:R-SSC-8851888] MET binds SHC1-2 - Sus scrofa [Reaction:R-SSC-8851890] MET phosphorylates SHC1-2 - Sus scrofa [Reaction:R-SSC-8851900] SHC1-2 bound to MET recruits GRB2:SOS1 - Sus scrofa [Reaction:R-SSC-8851899] RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET - Sus scrofa
inferredFrom	[Pathway:R-HSA-8851805] MET activates RAS signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	MET activates RAS signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49633] Sus scrofa
stId	R-SSC-8851805
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-6806834] Signaling by MET
(inferredTo)	[Pathway:R-HSA-8851805] MET activates RAS signaling

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