Reactome | PTK6 phosphorylates KHDRBS1

Schema > Reaction > Entries

PTK6 phosphorylates KHDRBS1 Show undefined attributes

authored	[InstanceEdit:8850988] Orlic-Milacic, Marija, 2016-01-04
catalystActivity	[CatalystActivity:8848974] protein tyrosine kinase activity of p-Y342-PTK6:KHDRBS1 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8848971] Orlic-Milacic, Marija, 2015-12-11
dbId	8848975
displayName	PTK6 phosphorylates KHDRBS1
edited	[InstanceEdit:8850988] Orlic-Milacic, Marija, 2016-01-04
eventOf	[Pathway:R-HSA-8849468] PTK6 Regulates Proteins Involved in RNA Processing - Homo sapiens
followingEvent	[Reaction:R-HSA-8848993] Phosphorylated KHDRBS1 translocates to the cytosol - Homo sapiens
input	3 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-HSA-8848940] p-Y342-PTK6:KHDRBS1 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8848980] Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression [LiteratureReference:8849047] Sam68 enhances the cytoplasmic utilization of intron-containing RNA and is functionally regulated by the nuclear kinase Sik/BRK [LiteratureReference:8848926] Sik (BRK) phosphorylates Sam68 in the nucleus and negatively regulates its RNA binding ability
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	PTK6 phosphorylates KHDRBS1
orthologousEvent	[Reaction:R-MMU-8848975] PTK6 phosphorylates KHDRBS1 - Mus musculus [Reaction:R-CEL-8848975] PTK6 phosphorylates KHDRBS1 - Caenorhabditis elegans [Reaction:R-XTR-8848975] PTK6 phosphorylates KHDRBS1 - Xenopus tropicalis [Reaction:R-DRE-8848975] PTK6 phosphorylates KHDRBS1 - Danio rerio [Reaction:R-SSC-8848975] PTK6 phosphorylates KHDRBS1 - Sus scrofa [Reaction:R-BTA-8848975] PTK6 phosphorylates KHDRBS1 - Bos taurus [Reaction:R-RNO-8848975] PTK6 phosphorylates KHDRBS1 - Rattus norvegicus
output	3 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8848937] p-Y342-PTK6 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8848970] p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-8848939] PTK6 binds KHDRBS1 - Homo sapiens
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8856649] Pires, Isabel M, 2016-02-07
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8848975
summation	[Summation:8848972] PTK6 phosphorylates KHDRBS1 (SAM68) on tyrosine residues Y43...

Referrals

(hasEvent)	[Pathway:R-HSA-8849468] PTK6 Regulates Proteins Involved in RNA Processing
(precedingEvent)	[Reaction:R-HSA-8848993] Phosphorylated KHDRBS1 translocates to the cytosol