Reactome | PTK6 Regulates Proteins Involved in RNA Processing

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PTK6 Regulates Proteins Involved in RNA Processing Show undefined attributes

authored	[InstanceEdit:8850988] Orlic-Milacic, Marija, 2016-01-04
created	[InstanceEdit:8849467] Orlic-Milacic, Marija, 2015-12-15
dbId	8849468
displayName	PTK6 Regulates Proteins Involved in RNA Processing
edited	[InstanceEdit:8850988] Orlic-Milacic, Marija, 2016-01-04
eventOf	[Pathway:R-HSA-8848021] Signaling by PTK6 - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-8848930] PTK6 translocates to the nucleus - Homo sapiens [Reaction:R-HSA-8848939] PTK6 binds KHDRBS1 - Homo sapiens [Reaction:R-HSA-8848975] PTK6 phosphorylates KHDRBS1 - Homo sapiens [Reaction:R-HSA-8848993] Phosphorylated KHDRBS1 translocates to the cytosol - Homo sapiens [Reaction:R-HSA-8849032] PTK6 phosphorylates KHDRBS2 - Homo sapiens [Reaction:R-HSA-8849042] PTK6 phosphorylates KHDRBS3 - Homo sapiens [Reaction:R-HSA-8849463] PTK6 phosphorylates SFPQ - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8848926] Sik (BRK) phosphorylates Sam68 in the nucleus and negatively regulates its RNA binding ability [LiteratureReference:8849033] The nuclear tyrosine kinase BRK/Sik phosphorylates and inhibits the RNA-binding activities of the Sam68-like mammalian proteins SLM-1 and SLM-2 [LiteratureReference:8849462] BRK phosphorylates PSF promoting its cytoplasmic localization and cell cycle arrest [LiteratureReference:8848980] Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression
maxDepth	2
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	PTK6 Regulates Proteins Involved in RNA Processing
orthologousEvent	[Pathway:R-MMU-8849468] PTK6 Regulates Proteins Involved in RNA Processing - Mus musculus [Pathway:R-CEL-8849468] PTK6 Regulates Proteins Involved in RNA Processing - Caenorhabditis elegans [Pathway:R-DME-8849468] PTK6 Regulates Proteins Involved in RNA Processing - Drosophila melanogaster [Pathway:R-GGA-8849468] PTK6 Regulates Proteins Involved in RNA Processing - Gallus gallus [Pathway:R-XTR-8849468] PTK6 Regulates Proteins Involved in RNA Processing - Xenopus tropicalis [Pathway:R-DRE-8849468] PTK6 Regulates Proteins Involved in RNA Processing - Danio rerio [Pathway:R-SSC-8849468] PTK6 Regulates Proteins Involved in RNA Processing - Sus scrofa [Pathway:R-BTA-8849468] PTK6 Regulates Proteins Involved in RNA Processing - Bos taurus [Pathway:R-RNO-8849468] PTK6 Regulates Proteins Involved in RNA Processing - Rattus norvegicus
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8856649] Pires, Isabel M, 2016-02-07
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-8849468
summation	[Summation:8849491] PTK6 binds and phosphorylates several nuclear RNA-binding pr...

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(hasEvent)

[Pathway:R-HSA-8848021] Signaling by PTK6

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