Reactome | SCD5 desaturates ST-CoA to OLE-CoA

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SCD5 desaturates ST-CoA to OLE-CoA Show undefined attributes

catalystActivity	[CatalystActivity:10306139] stearoyl-CoA 9-desaturase activity of SCD5 dimer [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10306141
displayName	SCD5 desaturates ST-CoA to OLE-CoA
eventOf	[Pathway:R-CFA-75105] Fatty acyl-CoA biosynthesis - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8847579] SCD5 desaturates ST-CoA to OLE-CoA - Homo sapiens
input	2 × [SimpleEntity:R-ALL-4085415] Fe(2+)Cb5 [cytosol] 2 × [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol] [SimpleEntity:R-ALL-428139] ST-CoA [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	SCD5 desaturates ST-CoA to OLE-CoA 2 Fe(II)-(cytochrome b5) + 2 H(+) + O2 + octadecanoyl-CoA => (9Z)-octadecenoyl-CoA + 2 Fe(III)-(cytochrome b5) + 2 H2O
output	2 × [SimpleEntity:R-ALL-4085425] Fe(3+)Cb5 [cytosol] 2 × [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-5690558] OLE-CoA [cytosol]
precedingEvent	[Reaction:R-CFA-548831] TECR,TECRL dehydrogenate TOD-CoA to ST-CoA - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-8847579
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-75105] Fatty acyl-CoA biosynthesis
(inferredTo)	[Reaction:R-HSA-8847579] SCD5 desaturates ST-CoA to OLE-CoA

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