Translocation of STAT1 dimer to nucleus

Stable Identifier
R-HSA-873917
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
nuclear envelope
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Translocation of STAT1 dimer to nucleus
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Released GAF complex translocates to the nucleus and binds to the gamma-activated sequence (GAS) element present in the promoters of IFNG-regulated genes and induces the transcription of IFNG-responsive genes.

Literature References
PubMed ID Title Journal Year
10982844 Regulation of STAT1 nuclear export by Jak1

David, M, Mowen, K

Mol Cell Biol 2000
12915721 The ins and outs of STAT1 nuclear transport

Reich, NC, McBride, KM

Sci STKE 2003
7510216 Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

Cowburn, D, Horvath, CM, Huang, LH, Darnell JE, Jr, Qureshi, SA, Shuai, K

Cell 1994
Participants
Input
Output
Participates
as an event of
Orthologous Events
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Translocation of STAT1 dimer to nucleus (Canis familiaris)
Translocation of STAT1 dimer to nucleus (Danio rerio)
Translocation of STAT1 dimer to nucleus (Dictyostelium discoideum)
Translocation of STAT1 dimer to nucleus (Drosophila melanogaster)
Translocation of STAT1 dimer to nucleus (Gallus gallus)
Translocation of STAT1 dimer to nucleus (Mus musculus)
Translocation of STAT1 dimer to nucleus (Rattus norvegicus)
Translocation of STAT1 dimer to nucleus (Xenopus tropicalis)
Authored
Garapati, P V  (2010-06-08)
Reviewed
Abdul-Sater, AA  (2010-08-17)
Schindler, C  (2010-08-17)
Created
Garapati, P V  (2010-06-08)
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