Reactome | SOCS3 gene expression is inhibited by RUNX1

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SOCS3 gene expression is inhibited by RUNX1 Show undefined attributes

authored	[InstanceEdit:8938982] Orlic-Milacic, Marija, 2016-09-14
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:8955884] Orlic-Milacic, Marija, 2017-01-13
dbId	8955885
displayName	SOCS3 gene expression is inhibited by RUNX1
edited	[InstanceEdit:9005626] Orlic-Milacic, Marija, 2017-05-09
eventOf	[Pathway:R-HSA-8939242] RUNX1 regulates transcription of genes involved in differentiation of keratinocytes - Homo sapiens
inferredFrom	[BlackBoxEvent:R-MMU-8955856] Socs3 gene expression is inhibited by Runx1 - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-8848151] SOCS3 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:8955594] Defining a tissue stem cell-driven Runx1/Stat3 signalling axis in epithelial cancer
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SOCS3 gene expression is inhibited by RUNX1
output	[EntityWithAccessionedSequence:R-HSA-873794] SOCS3 [cytosol]
precedingEvent	[Reaction:R-HSA-8955748] RUNX1 binds the SOCS3 gene - Homo sapiens
regulatedBy	[NegativeGeneExpressionRegulation:R-HSA-8955883] Negative gene expression regulation by 'RUNX1:CBFB:SOCS3 gene [nucleoplasm]'
regulationReference	[RegulationReference:9642515] Negative gene expression regulation by 'RUNX1:CBFB:SOCS3 gene [nucleoplasm]' Defining a tissue stem cell-driven Runx1/Stat3 signalling axis in epithelial cancer
releaseDate	2017-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9005627] Ito, Yoshiaki, 2016-12-20 [InstanceEdit:9005628] Chuang, Linda Shyue Huey, 2016-12-20
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-8955885
summation	[Summation:8955882] RUNX1, presumably in complex with CBFB, inhibits transcripti...

Referrals

(hasEvent)	[Pathway:R-HSA-8939242] RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
(inferredTo)	[BlackBoxEvent:R-MMU-8955856] Socs3 gene expression is inhibited by Runx1

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