Reactome | Socs3 [cytosol]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-MMU-8848108] p-Y342-PTK6:SOCS3 [cytosol] - Mus musculus [Complex:R-MMU-1112718] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] - Mus musculus
consumedByEvent	[Reaction:R-MMU-8848110] SOCS3 binds activated PTK6 - Mus musculus [Reaction:R-MMU-2672295] Phosphorylated Lepr Binds Socs3 - Mus musculus [Reaction:R-MMU-2672295] Phosphorylated Lepr Binds Socs3 - Mus musculus [Reaction:R-MMU-1112755] SOCS3 binds IL6ST - Mus musculus
created	[InstanceEdit:1169190] Jupe, S, 2011-01-13
dbId	1169197
displayName	Socs3 [cytosol]
endCoordinate	225
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-873794] SOCS3 [cytosol] - Homo sapiens
maxDepth	1
memberOf	[CandidateSet:R-MMU-1169187] Socs [cytosol] - Mus musculus [DefinedSet:R-MMU-8863155] CUL5-box protein [cytosol] - Mus musculus
name	Socs3 Suppressor of cytokine signaling 3 SOCS3_MOUSE Socs3
producedByEvent	[BlackBoxEvent:R-MMU-9705464] p-Y-Stat1,3,5 dimer enhances expression of Socs3 - Mus musculus [BlackBoxEvent:R-MMU-8955856] Socs3 gene expression is inhibited by Runx1 - Mus musculus
referenceEntity	[ReferenceGeneProduct:uniprot:O35718] UniProt:O35718 Socs3
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48892] Mus musculus
stId	R-MMU-1169197
startCoordinate	1

(input)	[Reaction:R-MMU-2672295] Phosphorylated Lepr Binds Socs3 [Reaction:R-MMU-1112755] SOCS3 binds IL6ST [Reaction:R-MMU-8848110] SOCS3 binds activated PTK6
(hasMember)	[CandidateSet:R-MMU-1169187] Socs [cytosol] [DefinedSet:R-MMU-9705446] Socs1,3 [cytosol] [DefinedSet:R-MMU-8863155] CUL5-box protein [cytosol] [DefinedSet:R-MMU-877267] SOCS-1 and SOCS-3 [cytosol]
(output)	[BlackBoxEvent:R-MMU-9705464] p-Y-Stat1,3,5 dimer enhances expression of Socs3 [BlackBoxEvent:R-MMU-8955856] Socs3 gene expression is inhibited by Runx1
(hasComponent)	[Complex:R-MMU-1112718] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] [Complex:R-MMU-2672300] Lep:p-Lepr:p-Jak2:Socs3 [plasma membrane] [Complex:R-MMU-8848108] p-Y342-PTK6:SOCS3 [cytosol]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-873794] SOCS3 [cytosol]