Reactome | FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8

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FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10339520
displayName	FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8
eventOf	[Pathway:R-BTA-75157] FasL/ CD95L signaling - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-3465459] FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling - Bos taurus [Reaction:R-BTA-5675456] FLIP(L) and procaspase-8 form heterodimer - Bos taurus [Reaction:R-BTA-3465429] FLIP(S) and procaspase-8 form heterodimer - Bos taurus [Reaction:R-BTA-73945] FAS-mediated dimerization of procaspase-8 - Bos taurus
inferredFrom	[Reaction:R-HSA-83586] FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 - Homo sapiens
input	[EntityWithAccessionedSequence:R-BTA-57031] CASP8 [cytosol] [Complex:R-BTA-43124] FASL:FAS Receptor Trimer:FADD [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8
output	[Complex:R-BTA-75114] FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane]
precedingEvent	[Reaction:R-BTA-83650] FasL:Fas binds FADD - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-83586
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-75157] FasL/ CD95L signaling
(precedingEvent)	[Reaction:R-BTA-3465459] FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling [Reaction:R-BTA-5675456] FLIP(L) and procaspase-8 form heterodimer [Reaction:R-BTA-3465429] FLIP(S) and procaspase-8 form heterodimer [Reaction:R-BTA-73945] FAS-mediated dimerization of procaspase-8
(inferredTo)	[Reaction:R-HSA-83586] FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8