Reactome | FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane]

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FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
consumedByEvent	[Reaction:R-HSA-3465459] FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling - Homo sapiens [Reaction:R-HSA-73945] FAS-mediated dimerization of procaspase-8 - Homo sapiens
dbId	75114
displayName	FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane]
hasComponent	[EntityWithAccessionedSequence:R-HSA-57031] CASP8(1-479) [cytosol] [Complex:R-HSA-43124] FASL:FAS Receptor Trimer:FADD [plasma membrane]
inDisease	false
includedLocation	[Compartment:70101] cytosol [Compartment:984] extracellular region
inferredTo	[Complex:R-MMU-75114] FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] - Mus musculus [Complex:R-RNO-75114] FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] - Rattus norvegicus [Complex:R-CFA-75114] FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] - Canis familiaris [Complex:R-BTA-75114] FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] - Bos taurus [Complex:R-SSC-75114] FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] - Sus scrofa [Complex:R-DRE-75114] FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] - Danio rerio [Complex:R-GGA-75114] FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] - Gallus gallus
literatureReference	[LiteratureReference:3465531] Fas-associated death domain protein and caspase-8 are not recruited to the tumor necrosis factor receptor 1 signaling complex during tumor necrosis factor-induced apoptosis [LiteratureReference:3465522] Ebselen sensitizes glioblastoma cells to Tumor Necrosis Factor (TNFalpha)-induced apoptosis through two distinct pathways involving NF-kappaB downregulation and Fas-mediated formation of death inducing signaling complex
maxDepth	5
modified	[InstanceEdit:5675028] Shamovsky, V, 2015-02-15
name	FASL:FAS trimer:FADD:CASP8(1-479)
producedByEvent	[Reaction:R-HSA-83586] FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-75114
updateTrackers	[UpdateTracker:9890337] Update Tracker - [Complex:75114] FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] - v52:[modifyName] [UpdateTracker:9889740] Update Tracker - [Complex:75114] FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] - v49:[updateContainedComponent] [UpdateTracker:9880382] Update Tracker - [Complex:75114] FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] - v45:[addLiteratureReference, updateContainedComponent] [UpdateTracker:9889093] Update Tracker - [Complex:75114] FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] - v48:[updateContainedComponent]

Referrals

(updatedInstance)	[UpdateTracker:9890337] Update Tracker - [Complex:75114] FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] - v52:[modifyName] [UpdateTracker:9889740] Update Tracker - [Complex:75114] FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] - v49:[updateContainedComponent] [UpdateTracker:9880382] Update Tracker - [Complex:75114] FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] - v45:[addLiteratureReference, updateContainedComponent] [UpdateTracker:9889093] Update Tracker - [Complex:75114] FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] - v48:[updateContainedComponent]
(input)	[Reaction:R-HSA-3465459] FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling [Reaction:R-HSA-73945] FAS-mediated dimerization of procaspase-8
(output)	[Reaction:R-HSA-83586] FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8

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