CYP1A2 S-demethylates 6MMP

Stable Identifier
R-HSA-76386
Type
Reaction [transition]
Species
Homo sapiens
Compartment
smooth endoplasmic reticulum
Synonyms
S-atom dealkylation of 6-methylmercaptopurine
ReviewStatus
5/5
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CYP1A2 S-demethylates 6MMP
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

At the beginning of this reaction, 1 molecule of 'H+', 1 molecule of '6-Methylmercaptopurine', 1 molecule of 'Oxygen', and 1 molecule of 'NADPH' are present. At the end of this reaction, 1 molecule of 'NADP+', 1 molecule of '6-Mercaptopurine', 1 molecule of 'Formaldehyde', and 1 molecule of 'H2O' are present.

This reaction takes place in the 'smooth endoplasmic reticulum' and is mediated by the 'oxygen binding activity' of 'Cytochrome P450 1A2 '.

Literature References
PubMed ID Title Journal Year
  Casarett and Doull's Toxicology 5th Edn

Parkinson, A

  1995
Participants
Input
Output
Participates
as an event of
Catalyst Activity

monooxygenase activity of CYP1A2 [endoplasmic reticulum membrane]

Physical Entity
CYP1A2 [endoplasmic reticulum membrane] (Homo sapiens)
Activity
monooxygenase activity (GO:0004497)
Orthologous Events
CYP1A2 S-demethylates 6MMP (Bos taurus)
CYP1A2 S-demethylates 6MMP (Danio rerio)
CYP1A2 S-demethylates 6MMP (Gallus gallus)
CYP1A2 S-demethylates 6MMP (Mus musculus)
CYP1A2 S-demethylates 6MMP (Rattus norvegicus)
CYP1A2 S-demethylates 6MMP (Sus scrofa)
CYP1A2 S-demethylates 6MMP (Xenopus tropicalis)
Created
Jassal, B  (2003-08-05)
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