Reactome | CYP1A2 S-demethylates 6MMP

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CYP1A2 S-demethylates 6MMP Show undefined attributes

catalystActivity	[CatalystActivity:10565311] monooxygenase activity of CYP1A2 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:17960] smooth endoplasmic reticulum
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10565315
displayName	CYP1A2 S-demethylates 6MMP
eventOf	[Pathway:R-DRE-156581] Methylation - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-158609] TPMT transfers CH3 from AdoMet to 6MP - Danio rerio
inferredFrom	[Reaction:R-HSA-76386] CYP1A2 S-demethylates 6MMP - Homo sapiens
input	[SimpleEntity:R-ALL-76384] 6MMP [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-156540] H+ [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113601] NADPH [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113534] O2 [endoplasmic reticulum lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	CYP1A2 S-demethylates 6MMP S-atom dealkylation of 6-methylmercaptopurine
output	[SimpleEntity:R-ALL-33153] 6MP [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-143501] CH2O [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113519] H2O [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113564] NADP+ [endoplasmic reticulum lumen]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-76386
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-156581] Methylation
(precedingEvent)	[Reaction:R-DRE-158609] TPMT transfers CH3 from AdoMet to 6MP
(inferredTo)	[Reaction:R-HSA-76386] CYP1A2 S-demethylates 6MMP

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