Reactome | XRCC4:LIG4 [nucleoplasm]

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XRCC4:LIG4 [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HSA-175440] viral DNA:Ku proteins:XRCC4:DNA ligase IV complex [nucleoplasm] - Homo sapiens [Complex:R-HSA-5693617] p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:XRCC4:LIG4:NHEJ1:POLL,POLM:Ligatable DNA DSB ends [nucleoplasm] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-5693574] XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ - Homo sapiens [Reaction:R-HSA-175177] Association of XRCC4:DNA ligase IV complex with viral DNA ends - Homo sapiens
created	[InstanceEdit:75904] Matthews, L, 2003-09-07 08:47:00
dbId	75912
displayName	XRCC4:LIG4 [nucleoplasm]
hasComponent	[EntityWithAccessionedSequence:R-HSA-53791] LIG4 [nucleoplasm] [Complex:R-HSA-5687210] XRCC4 homodimer [nucleoplasm]
inDisease	false
inferredTo	[Complex:R-MMU-75912] XRCC4:LIG4 [nucleoplasm] - Mus musculus [Complex:R-RNO-75912] XRCC4:LIG4 [nucleoplasm] - Rattus norvegicus [Complex:R-CFA-75912] XRCC4:LIG4 [nucleoplasm] - Canis familiaris [Complex:R-BTA-75912] XRCC4:LIG4 [nucleoplasm] - Bos taurus [Complex:R-SSC-75912] XRCC4:LIG4 [nucleoplasm] - Sus scrofa [Complex:R-DRE-75912] XRCC4:LIG4 [nucleoplasm] - Danio rerio [Complex:R-XTR-75912] XRCC4:LIG4 [nucleoplasm] - Xenopus tropicalis [Complex:R-GGA-75912] XRCC4:LIG4 [nucleoplasm] - Gallus gallus [Complex:R-DME-75912] XRCC4:LIG4 [nucleoplasm] - Drosophila melanogaster [Complex:R-DDI-75912] XRCC4:LIG4 [nucleoplasm] - Dictyostelium discoideum
literatureReference	[LiteratureReference:5687173] Crystal structure of an Xrcc4-DNA ligase IV complex
maxDepth	3
modified	[InstanceEdit:5687202] Orlic-Milacic, Marija, 2015-04-06
name	XRCC4:LIG4 XRCC4:DNA ligase IV complex
producedByEvent	[Reaction:R-HSA-175258] 2-LTR formation due to circularization of viral DNA - Homo sapiens [Reaction:R-HSA-5693604] XRCC4:LIG4 ligates DNA DSB ends during NHEJ - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-75912
updateTrackers	[UpdateTracker:9892389] Update Tracker - [Complex:75912] XRCC4:LIG4 [nucleoplasm] - v53:[addLiteratureReference, addName, add_removeHasComponent]

Referrals

(updatedInstance)	[UpdateTracker:9892389] Update Tracker - [Complex:75912] XRCC4:LIG4 [nucleoplasm] - v53:[addLiteratureReference, addName, add_removeHasComponent]
(input)	[Reaction:R-HSA-175177] Association of XRCC4:DNA ligase IV complex with viral DNA ends [Reaction:R-HSA-5693574] XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ
(output)	[Reaction:R-HSA-175258] 2-LTR formation due to circularization of viral DNA [Reaction:R-HSA-5693604] XRCC4:LIG4 ligates DNA DSB ends during NHEJ
(hasComponent)	[Complex:R-HSA-175440] viral DNA:Ku proteins:XRCC4:DNA ligase IV complex [nucleoplasm] [Complex:R-HSA-5687362] p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:XRCC4:LIG4:NHEJ1:POLL,POLM:Extended ligatable DNA DSB ends [nucleoplasm] [Complex:R-HSA-5693617] p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:XRCC4:LIG4:NHEJ1:POLL,POLM:Ligatable DNA DSB ends [nucleoplasm]

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