Reactome | 2-LTR formation due to circularization of viral DNA

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2-LTR formation due to circularization of viral DNA

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authored	[InstanceEdit:180401] Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22
catalystActivity	[CatalystActivity:175581] DNA ligase activity of viral DNA:Ku proteins:XRCC4:DNA ligase IV complex [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:175576] Gopinathrao, G, 2006-02-23 23:50:37
dbId	175258
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
displayName	2-LTR formation due to circularization of viral DNA
edited	[InstanceEdit:180401] Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22
eventOf	[Pathway:R-HSA-164843] 2-LTR circle formation - Homo sapiens
input	[Complex:R-HSA-175440] viral DNA:Ku proteins:XRCC4:DNA ligase IV complex [nucleoplasm]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:177403] Retroviral DNA integration--mechanism and consequences [Book:175927] 9780879695712 Integration Retroviruses Coffin, JM
modified	[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
name	2-LTR formation due to circularization of viral DNA
output	[Complex:R-HIV-175242] 2-LTR form of circular viral DNA [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-HIV-175288] IN (Integrase) (P04585) protein [nucleoplasm] [Complex:R-HSA-75912] XRCC4:LIG4 [nucleoplasm] [Complex:R-HSA-75905] XRCC5:XRCC6 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-175177] Association of XRCC4:DNA ligase IV complex with viral DNA ends - Homo sapiens
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2005-06-13
reviewed	[InstanceEdit:188934] Bushman, FD, 2006-10-30 22:19:13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-175258
summation	[Summation:180171] Viral DNA that does not become integrated can undergo anothe...

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[Pathway:R-HSA-164843] 2-LTR circle formation - Homo sapiens

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