Reactome | XRCC4:LIG4 ligates DNA DSB ends during NHEJ

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XRCC4:LIG4 ligates DNA DSB ends during NHEJ Show undefined attributes

authored	[InstanceEdit:75904] Matthews, L, 2003-09-07 08:47:00
catalystActivity	[CatalystActivity:5687220] DNA ligase activity of p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:XRCC4:LIG4:NHEJ1:POLL,POLM:Extended ligatable DNA DSB ends [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5693618] Orlic-Milacic, Marija, 2015-05-16
dbId	5693604
deleted	[Deleted:6793171] Deletion of instance: 75928
displayName	XRCC4:LIG4 ligates DNA DSB ends during NHEJ
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
eventOf	[Pathway:R-HSA-5693571] Nonhomologous End-Joining (NHEJ) - Homo sapiens
input	[Complex:R-HSA-5687362] p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:XRCC4:LIG4:NHEJ1:POLL,POLM:Extended ligatable DNA DSB ends [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:76322] DNA end-joining catalyzed by human cell-free extracts. [LiteratureReference:5687222] Identification of DNA-PKcs phosphorylation sites in XRCC4 and effects of mutations at these sites on DNA end joining in a cell-free system [LiteratureReference:5687240] XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining [LiteratureReference:5687239] Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly [LiteratureReference:5687244] Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends [LiteratureReference:5687424] XRCC4:DNA ligase IV can ligate incompatible DNA ends and can ligate across gaps [LiteratureReference:5687167] Artemis C-terminal region facilitates V(D)J recombination through its interactions with DNA Ligase IV and DNA-PKcs [LiteratureReference:5687173] Crystal structure of an Xrcc4-DNA ligase IV complex [LiteratureReference:5687201] Defining interactions between DNA-PK and ligase IV/XRCC4 [LiteratureReference:5687191] Ku recruits the XRCC4-ligase IV complex to DNA ends [LiteratureReference:5687401] Processing of damaged DNA ends for double-strand break repair in mammalian cells
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	XRCC4:LIG4 ligates DNA DSB ends during NHEJ
output	[DefinedSet:R-HSA-75927] ds DNA, mutated dsDNA [nucleoplasm] [Complex:R-HSA-5687234] NHEJ1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-5687176] p-S516,S645-DCLRE1C [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-HSA-76302] p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm] [DefinedSet:R-HSA-5687355] POLL,POLM [nucleoplasm] [Complex:R-HSA-75912] XRCC4:LIG4 [nucleoplasm] 2 × [Complex:R-HSA-75905] XRCC5:XRCC6 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5687360] POLL or POLM extends aligned DNA DSB ends to fill gaps - Homo sapiens
releaseDate	2003-11-03
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
revised	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5693604
summation	[Summation:5693541] The DNA ligase complex composed of DNA ligase 4 (LIG4) and t...

Referrals

(replacementInstances)	[Deleted:6793171] Deletion of instance: 75928
(hasEvent)	[Pathway:R-HSA-5693571] Nonhomologous End-Joining (NHEJ)

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