Reactome | Platelet Adhesion to exposed collagen

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Platelet Adhesion to exposed collagen Show undefined attributes

authored	[InstanceEdit:140345] de Bono, B, 2004-08-13 07:29:26
created	[InstanceEdit:141659] de Bono, B, Pace, N.P., Farndale, R, 2004-09-25 17:06:19
dbId	75892
diseasePathways	[Pathway:R-HSA-9846298] Defective binding of VWF variant to GPIb:IX:V - Homo sapiens [Pathway:R-HSA-9845619] Enhanced cleavage of VWF variant by ADAMTS13 - Homo sapiens [Pathway:R-HSA-9845621] Defective VWF cleavage by ADAMTS13 variant - Homo sapiens [Pathway:R-HSA-9845620] Enhanced binding of GP1BA variant to VWF multimer:collagen - Homo sapiens [Pathway:R-HSA-9845622] Defective VWF binding to collagen type I - Homo sapiens
displayName	Platelet Adhesion to exposed collagen
doi	10.3180/R-HSA-75892.6
edited	[InstanceEdit:9852766] Shamovsky, Veronica, 2023-11-07
eventOf	[TopLevelPathway:R-HSA-109582] Hemostasis - Homo sapiens
figure	[Figure:140200] /figures/hm_plt_adhesion.jpg
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-114563] Collagen type I binds integrin alpha1beta1, alpha2beta1, alpha10beta1 - Homo sapiens [Reaction:R-HSA-210282] Interaction of GPVI and FceRI gamma - Homo sapiens [Reaction:R-HSA-432295] GPVI binds Fyn and Lyn - Homo sapiens [Reaction:R-HSA-114577] Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen - Homo sapiens [Reaction:R-HSA-9822539] VWF multimer binds to collagen type I - Homo sapiens [Reaction:R-HSA-9823065] GPIb:IX:V binds to VWF multimer:collagen - Homo sapiens [BlackBoxEvent:R-HSA-9822532] ADAMTS13 cleaves VWF multimer - Homo sapiens [Reaction:R-HSA-9822734] Caplacizumab binds VWF - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2013-09-23
literatureReference	[LiteratureReference:139996] A novel association of Fc receptor gamma-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets [LiteratureReference:430219] Analysis of the interaction of platelet collagen receptor glycoprotein VI (GPVI) with collagen. A dimeric form of GPVI, but not the monomeric form, shows affinity to fibrous collagen
maxDepth	2
modified	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
name	Platelet Adhesion to exposed collagen
orthologousEvent	[Pathway:R-XTR-75892] Platelet Adhesion to exposed collagen - Xenopus tropicalis [Pathway:R-BTA-75892] Platelet Adhesion to exposed collagen - Bos taurus [Pathway:R-CFA-75892] Platelet Adhesion to exposed collagen - Canis familiaris [Pathway:R-RNO-75892] Platelet Adhesion to exposed collagen - Rattus norvegicus [Pathway:R-MMU-75892] Platelet Adhesion to exposed collagen - Mus musculus
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2004-10-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9853088] Gao, Rui, 2023-11-09
revised	[InstanceEdit:9822709] Shamovsky, Veronica, 2022-12-27
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-75892
summation	[Summation:140347] Initiation of platelet adhesion is the first step in the for...
updateTrackers	[UpdateTracker:9787141] Update Tracker - [Pathway:75892] Platelet Adhesion to exposed collagen - v46:[updateContainedRLE] [UpdateTracker:9853186] Update Tracker - [Pathway:75892] Platelet Adhesion to exposed collagen - v87:[add_removeHasEvent, modifyText, updateContainedRLE] [UpdateTracker:9787531] Update Tracker - [Pathway:75892] Platelet Adhesion to exposed collagen - v44:[modifyText, updateContainedRLE] [UpdateTracker:9788939] Update Tracker - [Pathway:75892] Platelet Adhesion to exposed collagen - v39:[removeHasEvent] [UpdateTracker:9791276] Update Tracker - [Pathway:75892] Platelet Adhesion to exposed collagen - v31:[addHasEvent] [UpdateTracker:9789406] Update Tracker - [Pathway:75892] Platelet Adhesion to exposed collagen - v38:[addLiteratureReference, add_removeHasEvent, modifyText, updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9787141] Update Tracker - [Pathway:75892] Platelet Adhesion to exposed collagen - v46:[updateContainedRLE] [UpdateTracker:9853186] Update Tracker - [Pathway:75892] Platelet Adhesion to exposed collagen - v87:[add_removeHasEvent, modifyText, updateContainedRLE] [UpdateTracker:9787531] Update Tracker - [Pathway:75892] Platelet Adhesion to exposed collagen - v44:[modifyText, updateContainedRLE] [UpdateTracker:9788939] Update Tracker - [Pathway:75892] Platelet Adhesion to exposed collagen - v39:[removeHasEvent] [UpdateTracker:9791276] Update Tracker - [Pathway:75892] Platelet Adhesion to exposed collagen - v31:[addHasEvent] [UpdateTracker:9789406] Update Tracker - [Pathway:75892] Platelet Adhesion to exposed collagen - v38:[addLiteratureReference, add_removeHasEvent, modifyText, updateContainedRLE]
(hasEvent)	[TopLevelPathway:R-HSA-109582] Hemostasis
(normalPathway)	[Pathway:R-HSA-9846298] Defective binding of VWF variant to GPIb:IX:V [Pathway:R-HSA-9845619] Enhanced cleavage of VWF variant by ADAMTS13 [Pathway:R-HSA-9845621] Defective VWF cleavage by ADAMTS13 variant [Pathway:R-HSA-9845620] Enhanced binding of GP1BA variant to VWF multimer:collagen [Pathway:R-HSA-9845622] Defective VWF binding to collagen type I

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