Reactome | GPVI binds Fyn and Lyn

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GPVI binds Fyn and Lyn Show undefined attributes

authored	[InstanceEdit:425201] Akkerman, JW, 2009-06-03
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:432296] Jupe, S, 2009-08-13
dbId	432295
displayName	GPVI binds Fyn and Lyn
edited	[InstanceEdit:445651] Jupe, S, 2009-11-02
eventOf	[Pathway:R-HSA-75892] Platelet Adhesion to exposed collagen - Homo sapiens
followingEvent	[Reaction:R-HSA-114577] Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-200917] FYN [cytosol] [Complex:R-HSA-114575] GP VI : FceRI gamma dimer [plasma membrane] [EntityWithAccessionedSequence:R-HSA-354251] LYN [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:210193] Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling
maxDepth	1
modified	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
name	GPVI binds Fyn and Lyn
orthologousEvent	[Reaction:R-XTR-432295] GPVI binds Fyn and Lyn - Xenopus tropicalis [Reaction:R-BTA-432295] GPVI binds Fyn and Lyn - Bos taurus [Reaction:R-CFA-432295] GPVI binds Fyn and Lyn - Canis familiaris [Reaction:R-RNO-432295] GPVI binds Fyn and Lyn - Rattus norvegicus [Reaction:R-MMU-432295] GPVI binds Fyn and Lyn - Mus musculus
output	[Complex:R-HSA-432297] GPVI:FceRI gamma:FYN:LYN [plasma membrane]
precedingEvent	[Reaction:R-HSA-210282] Interaction of GPVI and FceRI gamma - Homo sapiens
releaseDate	2009-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:445650] Poole, AW, 2009-11-02 [InstanceEdit:445653] Jones, ML, 2009-11-02 [InstanceEdit:445649] Harper, MT, 2009-11-02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-432295
summation	[Summation:432294] Fyn and Lyn constitutively associate with GPVI-Fc epsilon R1...

Referrals

(hasEvent)	[Pathway:R-HSA-75892] Platelet Adhesion to exposed collagen
(precedingEvent)	[Reaction:R-HSA-114577] Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen