Reactome | Defective VWF cleavage by ADAMTS13 variant

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Defective VWF cleavage by ADAMTS13 variant Show undefined attributes

authored	[InstanceEdit:9823584] Shamovsky, Veronica, 2023-01-07
created	[InstanceEdit:9845623] Shamovsky, Veronica, 2023-10-06
crossReference	[DatabaseIdentifier:12020796] Mondo:0000009
dbId	9845621
disease	[Disease:9705355] blood platelet disease
displayName	Defective VWF cleavage by ADAMTS13 variant
edited	[InstanceEdit:9852766] Shamovsky, Veronica, 2023-11-07
eventOf	[Pathway:R-HSA-9823587] Defects of platelet adhesion to exposed collagen - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[FailedReaction:R-HSA-9824402] ADAMTS13 variant does not cleave VWF multimer - Homo sapiens
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9824389] Mutations and common polymorphisms in ADAMTS13 gene responsible for von Willebrand factor-cleaving protease activity [LiteratureReference:9824416] Identification of novel mutations in ADAMTS13 in an adult patient with congenital thrombotic thrombocytopenic purpura [LiteratureReference:9824390] Inherited ADAMTS13 mutations associated with Thrombotic Thrombocytopenic Purpura: a short review and update
maxDepth	2
modified	[InstanceEdit:9852910] Shamovsky, Veronica, 2023-11-07
name	Defective VWF cleavage by ADAMTS13 variant
normalPathway	[Pathway:R-HSA-75892] Platelet Adhesion to exposed collagen
releaseDate	2023-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9852868] Gao, Rui, 2023-11-06
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9845621
summation	[Summation:9846323] Under normal physiological conditions, a disintegrin and met...

Referrals

(hasEvent)

[Pathway:R-HSA-9823587] Defects of platelet adhesion to exposed collagen

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