Reactome | GPIb:IX:V binds to VWF multimer:collagen

Schema > Reaction > Entries

GPIb:IX:V binds to VWF multimer:collagen Show undefined attributes

authored	[InstanceEdit:9822535] Shamovsky, Veronica, 2022-12-25
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9823066] Shamovsky, Veronica, 2023-01-04
dbId	9823065
diseaseReaction	[FailedReaction:R-HSA-9823706] VWF variant does not bind GPIb:IX:V - Homo sapiens [Reaction:R-HSA-9844251] GP1BA variant binds to VWF multimer:collagen - Homo sapiens
displayName	GPIb:IX:V binds to VWF multimer:collagen
edited	[InstanceEdit:9852766] Shamovsky, Veronica, 2023-11-07
eventOf	[Pathway:R-HSA-75892] Platelet Adhesion to exposed collagen - Homo sapiens
input	[Complex:R-HSA-9822536] Collagen type I fibril:VWF multimer [extracellular region] [Complex:R-HSA-9823064] GP1BA:GP1BB:GP9:GP5 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:140136] von Willebrand factor binding to platelet GpIb initiates signals for platelet activation [LiteratureReference:9823078] Crystal structure of the wild-type von Willebrand factor A1-glycoprotein Ibalpha complex reveals conformation differences with a complex bearing von Willebrand disease mutations [LiteratureReference:9823077] The N-terminal flanking region of the A1 domain regulates the force-dependent binding of von Willebrand factor to platelet glycoprotein Ib?
maxDepth	1
modified	[InstanceEdit:9852926] Shamovsky, Veronica, 2023-11-07
name	GPIb:IX:V binds to VWF multimer:collagen
output	[Complex:R-HSA-9823506] GP1BA:GP1BB:GP9:GP5:VWF:collagen type I [plasma membrane]
precedingEvent	[Reaction:R-HSA-9822539] VWF multimer binds to collagen type I - Homo sapiens
regulatedBy	[NegativeRegulation:9823280] Negative regulation by 'Collagen type I fibril:cleaved VWF multimer [extracellular region]' [NegativeRegulation:9823278] Negative regulation by 'Caplacizumab:VWF:collagen type I [extracellular region]'
releaseDate	2023-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9852925] Gao, Rui, 2023-11-07
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9823065
summation	[Summation:9823062] The initial tethering of platelets at sites of vascular inju...

Referrals

(normalReaction)	[FailedReaction:R-HSA-9823706] VWF variant does not bind GPIb:IX:V [Reaction:R-HSA-9844251] GP1BA variant binds to VWF multimer:collagen
(hasEvent)	[Pathway:R-HSA-75892] Platelet Adhesion to exposed collagen