Reactome | Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13

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Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 Show undefined attributes

authored	[InstanceEdit:745612] Jupe, S, 2010-05-18
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:751025] Jupe, S, 2010-05-19
dbId	751027
displayName	Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13
edited	[InstanceEdit:813668] Jupe, S, 2010-05-26
eventOf	[Pathway:R-HSA-416482] G alpha (12/13) signalling events - Homo sapiens
followingEvent	[Reaction:R-HSA-751029] Liganded G12/13-activating GPCR acts as a GEF for G12/13 - Homo sapiens
input	[DefinedSet:R-HSA-398082] G-protein G12/G13 (inactive) [plasma membrane] [DefinedSet:R-HSA-751003] Ligand:GPCR complexes that activate G12/13 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:750992] Receptors coupled to heterotrimeric G proteins of the G12 family [LiteratureReference:448849] Thromboxane A2: physiology/pathophysiology, cellular signal transduction and pharmacology [LiteratureReference:751000] Galpha(12/13) mediates alpha(1)-adrenergic receptor-induced cardiac hypertrophy
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13
orthologousEvent	[Reaction:R-CEL-751027] Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 - Caenorhabditis elegans [Reaction:R-GGA-751027] Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 - Gallus gallus [Reaction:R-BTA-751027] Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 - Bos taurus [Reaction:R-CFA-751027] Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 - Canis familiaris [Reaction:R-MMU-751027] Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 - Mus musculus
output	[Complex:R-HSA-750994] Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive). [plasma membrane]
precedingEvent	[Reaction:R-HSA-391939] TP receptor can bind thromboxane - Homo sapiens [Reaction:R-HSA-390641] ADRA1A,B,D bind ADR,NAd - Homo sapiens
releaseDate	2010-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:782850] D'Eustachio, P, 2010-05-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-751027
summation	[Summation:804956] About 25 receptors are reported to couple to the G12/13 G pr...

Referrals

(hasEvent)	[Pathway:R-HSA-416482] G alpha (12/13) signalling events
(precedingEvent)	[Reaction:R-HSA-751029] Liganded G12/13-activating GPCR acts as a GEF for G12/13

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