Reactome | Liganded G12/13-activating GPCR acts as a GEF for G12/13

Schema > Reaction > Entries

Liganded G12/13-activating GPCR acts as a GEF for G12/13 Show undefined attributes

authored	[InstanceEdit:392024] Jupe, S, 2009-02-26 15:51:29
catalystActivity	[CatalystActivity:763959] guanyl-nucleotide exchange factor activity of Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive). [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:751025] Jupe, S, 2010-05-19
dbId	751029
displayName	Liganded G12/13-activating GPCR acts as a GEF for G12/13
edited	[InstanceEdit:813668] Jupe, S, 2010-05-26
eventOf	[Pathway:R-HSA-416482] G alpha (12/13) signalling events - Homo sapiens
followingEvent	[Reaction:R-HSA-751019] The Ligand:GPCR:G12/13 complex dissociates - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-750994] Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive). [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:751004] Regulation and physiological functions of G12/13-mediated signaling pathways
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Liganded G12/13-activating GPCR acts as a GEF for G12/13
orthologousEvent	[Reaction:R-CEL-751029] Liganded G12/13-activating GPCR acts as a GEF for G12/13 - Caenorhabditis elegans [Reaction:R-DME-751029] Liganded G12/13-activating GPCR acts as a GEF for G12/13 - Drosophila melanogaster [Reaction:R-GGA-751029] Liganded G12/13-activating GPCR acts as a GEF for G12/13 - Gallus gallus [Reaction:R-XTR-751029] Liganded G12/13-activating GPCR acts as a GEF for G12/13 - Xenopus tropicalis [Reaction:R-DRE-751029] Liganded G12/13-activating GPCR acts as a GEF for G12/13 - Danio rerio [Reaction:R-SSC-751029] Liganded G12/13-activating GPCR acts as a GEF for G12/13 - Sus scrofa [Reaction:R-BTA-751029] Liganded G12/13-activating GPCR acts as a GEF for G12/13 - Bos taurus [Reaction:R-CFA-751029] Liganded G12/13-activating GPCR acts as a GEF for G12/13 - Canis familiaris [Reaction:R-RNO-751029] Liganded G12/13-activating GPCR acts as a GEF for G12/13 - Rattus norvegicus [Reaction:R-MMU-751029] Liganded G12/13-activating GPCR acts as a GEF for G12/13 - Mus musculus
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-751015] Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (active). [plasma membrane]
precedingEvent	[Reaction:R-HSA-751027] Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 - Homo sapiens
releaseDate	2010-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:782850] D'Eustachio, P, 2010-05-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-751029
summation	[Summation:751022] The liganded receptor undergoes a conformational change, gen...
updateTrackers	[UpdateTracker:9939757] Update Tracker - [Reaction:751029] Liganded G12/13-activating GPCR acts as a GEF for G12/13 - v92:[modifyText] [UpdateTracker:9781637] Update Tracker - [Reaction:751029] Liganded G12/13-activating GPCR acts as a GEF for G12/13 - v60:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9939757] Update Tracker - [Reaction:751029] Liganded G12/13-activating GPCR acts as a GEF for G12/13 - v92:[modifyText] [UpdateTracker:9781637] Update Tracker - [Reaction:751029] Liganded G12/13-activating GPCR acts as a GEF for G12/13 - v60:[modifyText]
(hasEvent)	[Pathway:R-HSA-416482] G alpha (12/13) signalling events
(precedingEvent)	[Reaction:R-HSA-751019] The Ligand:GPCR:G12/13 complex dissociates

Cite Us!