Reactome | Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13

Schema > Reaction > Entries

Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10942489
displayName	Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13
eventOf	[Pathway:R-CEL-416482] G alpha (12/13) signalling events - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-751029] Liganded G12/13-activating GPCR acts as a GEF for G12/13 - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-751027] Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 - Homo sapiens
input	[Complex:R-CEL-390633] ADRA1A,B,D:ADR,NAd [plasma membrane] [DefinedSet:R-CEL-398082] G-protein G12/G13 (inactive) [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13
output	[Complex:R-CEL-750994] Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive). [plasma membrane]
precedingEvent	[Reaction:R-CEL-390641] ADRA1A,B,D bind ADR,NAd - Caenorhabditis elegans
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-751027
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-416482] G alpha (12/13) signalling events
(precedingEvent)	[Reaction:R-CEL-751029] Liganded G12/13-activating GPCR acts as a GEF for G12/13
(inferredTo)	[Reaction:R-HSA-751027] Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13

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