Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13

Stable Identifier
Reaction [binding]
Homo sapiens
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About 25 receptors are reported to couple to the G12/13 G protein subtype (Riobo & Manning, 2005).Direct assay methods have not identified a receptor that only couples with G12. At least one receptor (5-HT4) only couples with G13, but most other receptors are reported to couple with both G12 and G13.

Literature References
PubMed ID Title Journal Year
18374420 Thromboxane A2: physiology/pathophysiology, cellular signal transduction and pharmacology

Nakahata, N

Pharmacol Ther 2008
15749160 Receptors coupled to heterotrimeric G proteins of the G12 family

Riobo, NA, Manning, DR

Trends Pharmacol Sci 2005
12433842 Galpha(12/13) mediates alpha(1)-adrenergic receptor-induced cardiac hypertrophy

Maruyama, Y, Nishida, M, Sugimoto, Y, Tanabe, S, Turner, JH, Kozasa, T, Wada, T, Nagao, T, Kurose, H

Circ Res 2002
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Orthologous Events
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