Reactome | Binding of SHC1 to insulin receptor

Schema > Reaction > Entries

Binding of SHC1 to insulin receptor Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:74963] Bevan, AP, 2003-07-31 08:01:55
dbId	74740
displayName	Binding of SHC1 to insulin receptor
eventOf	[Pathway:R-HSA-74751] Insulin receptor signalling cascade - Homo sapiens
followingEvent	[Reaction:R-HSA-74742] Phosphorylation of SHC1 - Homo sapiens
input	[Complex:R-HSA-74678] Insulin:p-6Y-Insulin receptor [plasma membrane] [EntityWithAccessionedSequence:R-HSA-74680] SHC1 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8984437] Insulin receptor substrate-1 enhances growth hormone-induced proliferation [LiteratureReference:8984404] Functional importance of amino-terminal domain of Shc for interaction with insulin and epidermal growth factor receptors in phosphorylation-independent manner
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Binding of SHC1 to insulin receptor
negativePrecedingEvent	[NegativePrecedingEvent:9865955] Futile Cycle: De-phosphorylation of p-Y427-SHC1 [NegativePrecedingEvent:9865956] Futile Cycle: Dissociation of IRS-P from insulin receptor [NegativePrecedingEvent:9865960] Futile Cycle: Dissociation of p-Y427-SHC1 from insulin receptor
orthologousEvent	[Reaction:R-GGA-74740] Binding of SHC1 to insulin receptor - Gallus gallus [Reaction:R-SSC-74740] Binding of SHC1 to insulin receptor - Sus scrofa [Reaction:R-BTA-74740] Binding of SHC1 to insulin receptor - Bos taurus [Reaction:R-CFA-74740] Binding of SHC1 to insulin receptor - Canis familiaris [Reaction:R-RNO-74740] Binding of SHC1 to insulin receptor - Rattus norvegicus [Reaction:R-MMU-74740] Binding of SHC1 to insulin receptor - Mus musculus
output	[Complex:R-HSA-74681] Insulin:p-6Y-Insulin receptor:SHC1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-74715] Autophosphorylation of insulin receptor - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-110031] Negative regulation by 'GRB10:INSR [plasma membrane]'
regulationReference	[RegulationReference:9641227] Negative regulation by 'GRB10:INSR [plasma membrane]' Negative regulation of insulin-stimulated mitogen-activated protein kinase signaling by Grb10.
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-74740
summation	[Summation:74745] SHC1 interacts via its SH2 domain with the carboxyterminal p...
updateTrackers	[UpdateTracker:9786120] Update Tracker - [Reaction:74740] Binding of SHC1 to insulin receptor - v50:[add_removeRegulator] [UpdateTracker:9784808] Update Tracker - [Reaction:74740] Binding of SHC1 to insulin receptor - v53:[add_removeSummation] [UpdateTracker:9781213] Update Tracker - [Reaction:74740] Binding of SHC1 to insulin receptor - v61:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9786120] Update Tracker - [Reaction:74740] Binding of SHC1 to insulin receptor - v50:[add_removeRegulator] [UpdateTracker:9784808] Update Tracker - [Reaction:74740] Binding of SHC1 to insulin receptor - v53:[add_removeSummation] [UpdateTracker:9781213] Update Tracker - [Reaction:74740] Binding of SHC1 to insulin receptor - v61:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-74751] Insulin receptor signalling cascade
(precedingEvent)	[Reaction:R-HSA-74742] Phosphorylation of SHC1

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