Reactome | Autophosphorylation of insulin receptor

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Autophosphorylation of insulin receptor Show undefined attributes

authored	[InstanceEdit:74963] Bevan, AP, 2003-07-31 08:01:55
catalystActivity	[CatalystActivity:74714] insulin receptor activity of Insulin:Insulin receptor [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:74963] Bevan, AP, 2003-07-31 08:01:55
dbId	74715
displayName	Autophosphorylation of insulin receptor
eventOf	[Pathway:R-HSA-74752] Signaling by Insulin receptor - Homo sapiens
figure	[Figure:74817] /figures/ins_autoph.jpg
followingEvent	[Reaction:R-HSA-110011] Binding of Grb10 to the insulin receptor - Homo sapiens [Reaction:R-HSA-74707] Binding of IRS to insulin receptor - Homo sapiens [Reaction:R-HSA-74740] Binding of SHC1 to insulin receptor - Homo sapiens [BlackBoxEvent:R-HSA-74718] Internalisation of the insulin receptor - Homo sapiens
input	12 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-74703] Insulin:Insulin receptor [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5685347] Studies on the autophosphorylation of the insulin receptor from human placenta. Analysis of the sites phosphorylated by two-dimensional peptide mapping
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Autophosphorylation of insulin receptor
orthologousEvent	[Reaction:R-GGA-74715] Autophosphorylation of insulin receptor - Gallus gallus [Reaction:R-XTR-74715] Autophosphorylation of insulin receptor - Xenopus tropicalis [Reaction:R-DRE-74715] Autophosphorylation of insulin receptor - Danio rerio [Reaction:R-SSC-74715] Autophosphorylation of insulin receptor - Sus scrofa [Reaction:R-BTA-74715] Autophosphorylation of insulin receptor - Bos taurus [Reaction:R-CFA-74715] Autophosphorylation of insulin receptor - Canis familiaris [Reaction:R-RNO-74715] Autophosphorylation of insulin receptor - Rattus norvegicus [Reaction:R-MMU-74715] Autophosphorylation of insulin receptor - Mus musculus
output	12 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-74678] Insulin:p-6Y-Insulin receptor [plasma membrane]
precedingEvent	[Reaction:R-HSA-74716] Insulin binds the insulin receptor - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-74715
summation	[Summation:74755] Receptor autophosphorylation requires a lysine at position 1...
updateTrackers	[UpdateTracker:9784689] Update Tracker - [Reaction:74715] Autophosphorylation of insulin receptor - v53:[add_removeLiteratureReference, modifyText] [UpdateTracker:9781065] Update Tracker - [Reaction:74715] Autophosphorylation of insulin receptor - v61:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9784689] Update Tracker - [Reaction:74715] Autophosphorylation of insulin receptor - v53:[add_removeLiteratureReference, modifyText] [UpdateTracker:9781065] Update Tracker - [Reaction:74715] Autophosphorylation of insulin receptor - v61:[modifyText]
(hasEvent)	[Pathway:R-HSA-74752] Signaling by Insulin receptor
(precedingEvent)	[Reaction:R-HSA-110011] Binding of Grb10 to the insulin receptor [Reaction:R-HSA-74707] Binding of IRS to insulin receptor [Reaction:R-HSA-74740] Binding of SHC1 to insulin receptor [BlackBoxEvent:R-HSA-74718] Internalisation of the insulin receptor

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