Binding of SHC1 to insulin receptor

Stable Identifier
R-HSA-74740
Type
Reaction
Species
Homo sapiens
Compartment
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SHC1 interacts via its SH2 domain with the carboxyterminal phosphorylated tyrosines of the insulin receptor. As a result, SHC1 is tyrosine phosphorylated by the insulin receptor, later falling away from the receptor (Liang et al.1999, Sasaoka et al.1996).

Literature References
PubMed ID Title Journal Year
8702728 Functional importance of amino-terminal domain of Shc for interaction with insulin and epidermal growth factor receptors in phosphorylation-independent manner

Imamura, T, Sawa, T, Sasaoka, T, Usui, I, Takata, Y, Ishihara, H, Kobayashi, M, Morioka, H, Ishiki, M

J. Biol. Chem. 1996
10218944 Insulin receptor substrate-1 enhances growth hormone-induced proliferation

Zhou, T, Frank, SJ, Gustafson, TA, Liang, L, Jiang, J, Pierce, JH

Endocrinology 1999
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