Reactome | Phosphorylation of SHC1

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Phosphorylation of SHC1 Show undefined attributes

catalystActivity	[CatalystActivity:74741] transmembrane receptor protein tyrosine kinase activity of Insulin:p-6Y-Insulin receptor:SHC1 [plasma membrane]
category	transition
compartment	[Compartment:947587] cytoplasmic side of plasma membrane
created	[InstanceEdit:74963] Bevan, AP, 2003-07-31 08:01:55
dbId	74742
displayName	Phosphorylation of SHC1
eventOf	[Pathway:R-HSA-74751] Insulin receptor signalling cascade - Homo sapiens
followingEvent	[Reaction:R-HSA-74743] Dissociation of p-Y427-SHC1 from insulin receptor - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-74681] Insulin:p-6Y-Insulin receptor:SHC1 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5685352] The functional significance of Shc in insulin signaling as a substrate of the insulin receptor [LiteratureReference:8984404] Functional importance of amino-terminal domain of Shc for interaction with insulin and epidermal growth factor receptors in phosphorylation-independent manner
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Phosphorylation of SHC1
orthologousEvent	[Reaction:R-XTR-74742] Phosphorylation of SHC1 - Xenopus tropicalis [Reaction:R-GGA-74742] Phosphorylation of SHC1 - Gallus gallus [Reaction:R-SSC-74742] Phosphorylation of SHC1 - Sus scrofa [Reaction:R-BTA-74742] Phosphorylation of SHC1 - Bos taurus [Reaction:R-CFA-74742] Phosphorylation of SHC1 - Canis familiaris [Reaction:R-RNO-74742] Phosphorylation of SHC1 - Rattus norvegicus [Reaction:R-MMU-74742] Phosphorylation of SHC1 - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-74685] Insulin:p-6Y-Insulin receptor:p-Y427-SHC1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-74740] Binding of SHC1 to insulin receptor - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-74742
summation	[Summation:179079] SHC1 is tyrosine phosphorylated at Tyr-427 by the insulin re...
updateTrackers	[UpdateTracker:9781019] Update Tracker - [Reaction:74742] Phosphorylation of SHC1 - v61:[addLiteratureReference, modifyText] [UpdateTracker:9784832] Update Tracker - [Reaction:74742] Phosphorylation of SHC1 - v53:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9781019] Update Tracker - [Reaction:74742] Phosphorylation of SHC1 - v61:[addLiteratureReference, modifyText] [UpdateTracker:9784832] Update Tracker - [Reaction:74742] Phosphorylation of SHC1 - v53:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-74751] Insulin receptor signalling cascade
(precedingEvent)	[Reaction:R-HSA-74743] Dissociation of p-Y427-SHC1 from insulin receptor