Reactome | Binding of SHC1 to insulin receptor

Schema > Reaction > Entries

Binding of SHC1 to insulin receptor Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10451803
displayName	Binding of SHC1 to insulin receptor
eventOf	[Pathway:R-SSC-74751] Insulin receptor signalling cascade - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-74742] Phosphorylation of SHC1 - Sus scrofa
inferredFrom	[Reaction:R-HSA-74740] Binding of SHC1 to insulin receptor - Homo sapiens
input	[Complex:R-SSC-74678] Insulin:p-6Y-Insulin receptor [plasma membrane] [EntityWithAccessionedSequence:R-SSC-74680] SHC1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Binding of SHC1 to insulin receptor
output	[Complex:R-SSC-74681] Insulin:p-6Y-Insulin receptor:SHC1 [plasma membrane]
precedingEvent	[Reaction:R-SSC-74715] Autophosphorylation of insulin receptor - Sus scrofa
regulatedBy	[NegativeRegulation:10451546] Negative regulation by 'GRB10:INSR [plasma membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-74740
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-74751] Insulin receptor signalling cascade
(precedingEvent)	[Reaction:R-SSC-74742] Phosphorylation of SHC1
(inferredTo)	[Reaction:R-HSA-74740] Binding of SHC1 to insulin receptor

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