Reactome | HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP

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HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP Show undefined attributes

catalystActivity	[CatalystActivity:10736000] purine phosphoribosyltransferase activity of HPRT1 tetramer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10736002
displayName	HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP
eventOf	[Pathway:R-GGA-74217] Purine salvage - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-514604] GMP + NADPH + 2 H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) - Gallus gallus [Reaction:R-GGA-74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) - Gallus gallus [Reaction:R-GGA-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate - Gallus gallus
inferredFrom	[Reaction:R-HSA-74215] HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP - Homo sapiens
input	[DefinedSet:R-ALL-500259] Gua, Hyp [cytosol] [SimpleEntity:R-ALL-73566] PRPP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP guanine or hypoxanthine + PRPP => GMP or IMP + PPi (HPRT1) guanine + 5-phospho-alpha-D-ribose 1-diphosphate => GMP + diphosphate hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate => IMP + diphosphate
output	[DefinedSet:R-ALL-500260] GMP, IMP [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-74215
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-GGA-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate [Reaction:R-GGA-514604] GMP + NADPH + 2 H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) [Reaction:R-GGA-74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)
(hasEvent)	[Pathway:R-GGA-74217] Purine salvage
(inferredTo)	[Reaction:R-HSA-74215] HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP

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