Reactome | 2 acetyl-CoA <=> acetoacetyl-CoA + CoA

Schema > Reaction > Entries

2 acetyl-CoA <=> acetoacetyl-CoA + CoA Show undefined attributes

catalystActivity	[CatalystActivity:70842] acetyl-CoA C-acetyltransferase activity of ACAT1 tetramer [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9643975] acetyl-CoA C-acetyltransferase activity of ACAT1 tetramer [mitochondrial matrix] Crystallographic and kinetic studies of human mitochondrial acetoacetyl-CoA thiolase: the importance of potassium and chloride ions for its structure and function
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:74168] Gopinathrao, G, 2003-07-16 00:00:00
crossReference	[DatabaseIdentifier:12667850] RHEA:21037
dbId	73916
displayName	2 acetyl-CoA <=> acetoacetyl-CoA + CoA
eventOf	[Pathway:R-HSA-77111] Synthesis of Ketone Bodies - Homo sapiens
followingEvent	[Reaction:R-HSA-73918] acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113559] Ac-CoA [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:200040] 3-Ketothiolase deficiency
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	2 acetyl-CoA <=> acetoacetyl-CoA + CoA
orthologousEvent	[Reaction:R-PFA-73916] 2 acetyl-CoA <=> acetoacetyl-CoA + CoA - Plasmodium falciparum [Reaction:R-DDI-73916] 2 acetyl-CoA <=> acetoacetyl-CoA + CoA - Dictyostelium discoideum [Reaction:R-CEL-73916] 2 acetyl-CoA <=> acetoacetyl-CoA + CoA - Caenorhabditis elegans [Reaction:R-DME-73916] 2 acetyl-CoA <=> acetoacetyl-CoA + CoA - Drosophila melanogaster [Reaction:R-GGA-73916] 2 acetyl-CoA <=> acetoacetyl-CoA + CoA - Gallus gallus [Reaction:R-DRE-73916] 2 acetyl-CoA <=> acetoacetyl-CoA + CoA - Danio rerio [Reaction:R-SSC-73916] 2 acetyl-CoA <=> acetoacetyl-CoA + CoA - Sus scrofa [Reaction:R-BTA-73916] 2 acetyl-CoA <=> acetoacetyl-CoA + CoA - Bos taurus [Reaction:R-CFA-73916] 2 acetyl-CoA <=> acetoacetyl-CoA + CoA - Canis familiaris [Reaction:R-RNO-73916] 2 acetyl-CoA <=> acetoacetyl-CoA + CoA - Rattus norvegicus [Reaction:R-MMU-73916] 2 acetyl-CoA <=> acetoacetyl-CoA + CoA - Mus musculus
output	[SimpleEntity:R-ALL-73871] ACA-CoA [mitochondrial matrix] [SimpleEntity:R-ALL-29374] CoA-SH [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-8875071] ACSS3 ligates CoA to CH3COO- - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-73916
summation	[Summation:178254] Acetyl-CoA acetyltransferase tetramer (ACAT1) in the mitocho...
updateTrackers	[UpdateTracker:9792334] Update Tracker - [Reaction:73916] 2 acetyl-CoA <=> acetoacetyl-CoA + CoA - v22:[addLiteratureReference] [UpdateTracker:9789151] Update Tracker - [Reaction:73916] 2 acetyl-CoA <=> acetoacetyl-CoA + CoA - v38:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9792334] Update Tracker - [Reaction:73916] 2 acetyl-CoA <=> acetoacetyl-CoA + CoA - v22:[addLiteratureReference] [UpdateTracker:9789151] Update Tracker - [Reaction:73916] 2 acetyl-CoA <=> acetoacetyl-CoA + CoA - v38:[modifyText]
(hasEvent)	[Pathway:R-HSA-77111] Synthesis of Ketone Bodies
(precedingEvent)	[Reaction:R-HSA-73918] acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH
(reverseReaction)	[Reaction:R-HSA-74181] acetoacetyl-CoA + CoA <=> 2 acetyl-CoA