Reactome | acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH

Schema > Reaction > Entries

acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH Show undefined attributes

catalystActivity	[CatalystActivity:74170] hydroxymethylglutaryl-CoA synthase activity of HMGCS2 [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:74168] Gopinathrao, G, 2003-07-16 00:00:00
crossReference	[DatabaseIdentifier:12667849] RHEA:10189
dbId	73918
displayName	acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH
eventOf	[Pathway:R-HSA-77111] Synthesis of Ketone Bodies - Homo sapiens
followingEvent	[Reaction:R-HSA-74180] HMG CoA => acetoacetic acid + acetyl CoA - Homo sapiens
input	[SimpleEntity:R-ALL-113559] Ac-CoA [mitochondrial matrix] [SimpleEntity:R-ALL-73871] ACA-CoA [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:200268] Genetic basis of mitochondrial HMG-CoA synthase deficiency
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH
orthologousEvent	[Reaction:R-SCE-73918] acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH - Saccharomyces cerevisiae [Reaction:R-SPO-73918] acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH - Schizosaccharomyces pombe [Reaction:R-DDI-73918] acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH - Dictyostelium discoideum [Reaction:R-CEL-73918] acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH - Caenorhabditis elegans [Reaction:R-DME-73918] acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH - Drosophila melanogaster [Reaction:R-GGA-73918] acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH - Gallus gallus [Reaction:R-XTR-73918] acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH - Xenopus tropicalis [Reaction:R-SSC-73918] acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH - Sus scrofa [Reaction:R-BTA-73918] acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH - Bos taurus [Reaction:R-CFA-73918] acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH - Canis familiaris [Reaction:R-RNO-73918] acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH - Rattus norvegicus [Reaction:R-MMU-73918] acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH - Mus musculus
output	[SimpleEntity:R-ALL-29374] CoA-SH [mitochondrial matrix] [SimpleEntity:R-ALL-73917] HMG CoA [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-73916] 2 acetyl-CoA <=> acetoacetyl-CoA + CoA - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-73918
summation	[Summation:178369] Hydroxymethylglutaryl-CoA synthase tetramer (HMGCS2) in the ...
updateTrackers	[UpdateTracker:9790671] Update Tracker - [Reaction:73918] acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH - v33:[addOutput] [UpdateTracker:9792392] Update Tracker - [Reaction:73918] acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH - v22:[addLiteratureReference] [UpdateTracker:9789141] Update Tracker - [Reaction:73918] acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH - v38:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9790671] Update Tracker - [Reaction:73918] acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH - v33:[addOutput] [UpdateTracker:9792392] Update Tracker - [Reaction:73918] acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH - v22:[addLiteratureReference] [UpdateTracker:9789141] Update Tracker - [Reaction:73918] acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH - v38:[modifyText]
(hasEvent)	[Pathway:R-HSA-77111] Synthesis of Ketone Bodies
(precedingEvent)	[Reaction:R-HSA-74180] HMG CoA => acetoacetic acid + acetyl CoA

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