Reactome | ACSS3 ligates CoA to CH3COO-

Schema > Reaction > Entries

ACSS3 ligates CoA to CH3COO- Show undefined attributes

authored	[InstanceEdit:8875072] Jassal, Bijay, 2016-06-01
catalystActivity	[CatalystActivity:8875070] acetate-CoA ligase activity of ACSS3 [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:8875072] Jassal, Bijay, 2016-06-01
crossReference	[DatabaseIdentifier:12668054] RHEA:23177
dbId	8875071
displayName	ACSS3 ligates CoA to CH3COO-
edited	[InstanceEdit:8875072] Jassal, Bijay, 2016-06-01
eventOf	[Pathway:R-HSA-77111] Synthesis of Ketone Bodies - Homo sapiens
followingEvent	[Reaction:R-HSA-73916] 2 acetyl-CoA <=> acetoacetyl-CoA + CoA - Homo sapiens
input	[SimpleEntity:R-ALL-113593] ATP [mitochondrial matrix] [SimpleEntity:R-ALL-113539] CH3COO- [mitochondrial matrix] [SimpleEntity:R-ALL-29374] CoA-SH [mitochondrial matrix]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5696002] Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	ACSS3 ligates CoA to CH3COO-
orthologousEvent	[Reaction:R-DDI-8875071] ACSS3 ligates CoA to CH3COO- - Dictyostelium discoideum [Reaction:R-DME-8875071] ACSS3 ligates CoA to CH3COO- - Drosophila melanogaster [Reaction:R-GGA-8875071] ACSS3 ligates CoA to CH3COO- - Gallus gallus [Reaction:R-XTR-8875071] ACSS3 ligates CoA to CH3COO- - Xenopus tropicalis [Reaction:R-SSC-8875071] ACSS3 ligates CoA to CH3COO- - Sus scrofa [Reaction:R-BTA-8875071] ACSS3 ligates CoA to CH3COO- - Bos taurus [Reaction:R-CFA-8875071] ACSS3 ligates CoA to CH3COO- - Canis familiaris [Reaction:R-RNO-8875071] ACSS3 ligates CoA to CH3COO- - Rattus norvegicus [Reaction:R-MMU-8875071] ACSS3 ligates CoA to CH3COO- - Mus musculus
output	[SimpleEntity:R-ALL-113559] Ac-CoA [mitochondrial matrix] [SimpleEntity:R-ALL-159448] AMP [mitochondrial matrix] [SimpleEntity:R-ALL-159450] PPi [mitochondrial matrix]
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8879141] D'Eustachio, Peter, 2016-07-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8875071
summation	[Summation:8875069] Mitochondrial acyl-CoA synthetase short-chain family member ...

Referrals

(hasEvent)	[Pathway:R-HSA-77111] Synthesis of Ketone Bodies
(precedingEvent)	[Reaction:R-HSA-73916] 2 acetyl-CoA <=> acetoacetyl-CoA + CoA