Reactome | acetoacetyl-CoA + CoA <=> 2 acetyl-CoA

Schema > Reaction > Entries

acetoacetyl-CoA + CoA <=> 2 acetyl-CoA Show undefined attributes

catalystActivity	[CatalystActivity:70842] acetyl-CoA C-acetyltransferase activity of ACAT1 tetramer [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9643975] acetyl-CoA C-acetyltransferase activity of ACAT1 tetramer [mitochondrial matrix] Crystallographic and kinetic studies of human mitochondrial acetoacetyl-CoA thiolase: the importance of potassium and chloride ions for its structure and function
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:74171] Gopinathrao, G, 2003-07-16 00:00:00
crossReference	[DatabaseIdentifier:11880899] Rhea:21038
dbId	74181
displayName	acetoacetyl-CoA + CoA <=> 2 acetyl-CoA
eventOf	[Pathway:R-HSA-77108] Utilization of Ketone Bodies - Homo sapiens
input	[SimpleEntity:R-ALL-73871] ACA-CoA [mitochondrial matrix] [SimpleEntity:R-ALL-29374] CoA-SH [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:200040] 3-Ketothiolase deficiency
modified	[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name	acetoacetyl-CoA + CoA <=> 2 acetyl-CoA
orthologousEvent	[Reaction:R-PFA-74181] acetoacetyl-CoA + CoA <=> 2 acetyl-CoA - Plasmodium falciparum [Reaction:R-DDI-74181] acetoacetyl-CoA + CoA <=> 2 acetyl-CoA - Dictyostelium discoideum [Reaction:R-CEL-74181] acetoacetyl-CoA + CoA <=> 2 acetyl-CoA - Caenorhabditis elegans [Reaction:R-DME-74181] acetoacetyl-CoA + CoA <=> 2 acetyl-CoA - Drosophila melanogaster [Reaction:R-GGA-74181] acetoacetyl-CoA + CoA <=> 2 acetyl-CoA - Gallus gallus [Reaction:R-XTR-74181] acetoacetyl-CoA + CoA <=> 2 acetyl-CoA - Xenopus tropicalis [Reaction:R-DRE-74181] acetoacetyl-CoA + CoA <=> 2 acetyl-CoA - Danio rerio [Reaction:R-SSC-74181] acetoacetyl-CoA + CoA <=> 2 acetyl-CoA - Sus scrofa [Reaction:R-BTA-74181] acetoacetyl-CoA + CoA <=> 2 acetyl-CoA - Bos taurus [Reaction:R-CFA-74181] acetoacetyl-CoA + CoA <=> 2 acetyl-CoA - Canis familiaris [Reaction:R-RNO-74181] acetoacetyl-CoA + CoA <=> 2 acetyl-CoA - Rattus norvegicus [Reaction:R-MMU-74181] acetoacetyl-CoA + CoA <=> 2 acetyl-CoA - Mus musculus
output	2 × [SimpleEntity:R-ALL-113559] Ac-CoA [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-74177] OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA - Homo sapiens
releaseDate	2004-07-06
reverseReaction	[Reaction:R-HSA-73916] 2 acetyl-CoA <=> acetoacetyl-CoA + CoA
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-74181
summation	[Summation:178370] Acetyl-CoA acetyltransferase tetramer (ACAT1) in the mitocho...

Referrals

(hasEvent)

[Pathway:R-HSA-77108] Utilization of Ketone Bodies