2 acetyl-CoA <=> acetoacetyl-CoA + CoA

Stable Identifier
R-HSA-73916
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
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2 acetyl-CoA <=> acetoacetyl-CoA + CoA
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Acetyl-CoA acetyltransferase tetramer (ACAT1) in the mitochondrial matrix catalyzes the reversible reaction of two molecules of acetyl-CoA to form acetoacetyl-CoA and CoA (Middleton et al. 1986).

Literature References
PubMed ID Title Journal Year
3709573 3-Ketothiolase deficiency

Middleton, B, Bartlett, K, Romanos, A, Gomez Vazquez, J, Conde, C, Cannon, RA, Lipson, M, Sweetman, L, Nyhan, WL

Eur J Pediatr 1986
Participants
Input
Output
Participant Of
hasEvent
Event Information
Reverse Reaction
acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Homo sapiens)
Catalyst Activity
Catalyst Activity
Title
acetyl-CoA C-acetyltransferase activity of ACAT1 tetramer [mitochondrial matrix]
Physical Entity
ACAT1 tetramer [mitochondrial matrix]
Activity
acetyl-CoA C-acetyltransferase activity (0003985)
Orthologous Events
2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Bos taurus)
2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Caenorhabditis elegans)
2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Canis familiaris)
2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Danio rerio)
2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Dictyostelium discoideum)
2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Drosophila melanogaster)
2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Gallus gallus)
2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Mus musculus)
2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Plasmodium falciparum)
2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Rattus norvegicus)
2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Sus scrofa)
2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Xenopus tropicalis)
Cross References
Rhea
Created
Gopinathrao, G  (2003-07-16)