2 acetyl-CoA <=> acetoacetyl-CoA + CoA

Stable Identifier
R-HSA-73916
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
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2 acetyl-CoA <=> acetoacetyl-CoA + CoA
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Acetyl-CoA acetyltransferase tetramer (ACAT1) in the mitochondrial matrix catalyzes the reversible reaction of two molecules of acetyl-CoA to form acetoacetyl-CoA and CoA (Middleton et al. 1986).

Literature References
PubMed ID Title Journal Year
3709573 3-Ketothiolase deficiency

Romanos, A, Middleton, B, Cannon, RA, Conde, C, Nyhan, WL, Lipson, M, Gomez Vazquez, J, Bartlett, K, Sweetman, L

Eur J Pediatr 1986
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Catalyst Activity

acetyl-CoA C-acetyltransferase activity of ACAT1 tetramer [mitochondrial matrix]

Physical Entity
ACAT1 tetramer [mitochondrial matrix] (Homo sapiens)
Activity
acetyl-CoA C-acetyltransferase activity (GO:0003985)
Orthologous Events
2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Bos taurus)
2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Caenorhabditis elegans)
2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Canis familiaris)
2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Danio rerio)
2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Dictyostelium discoideum)
2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Drosophila melanogaster)
2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Gallus gallus)
2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Mus musculus)
2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Plasmodium falciparum)
2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Rattus norvegicus)
2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Sus scrofa)
Cross References
Rhea
Created
Gopinathrao, G  (2003-07-16)
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