Cytosolic dihydropyrimidine dehydrogenase catalyzes the reaction of uracil and NADPH + H+ to form 5,6-dihydrouracil and NADP+. The mechanism of the human reaction is inferred from that of the well-characterized pig enzyme (Yokota et al. 1994).
Yokota, H, Fernandez-Salguero, P, Furuya, H, Lin, K, McBride, OW, Podschun, B, Schnackerz, KD, Gonzalez, FJ
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