uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+

Stable Identifier
R-HSA-73585
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
reduction of uracil to form dihydrouracil
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Cytosolic dihydropyrimidine dehydrogenase catalyzes the reaction of uracil and NADPH + H+ to form 5,6-dihydrouracil and NADP+. The mechanism of the human reaction is inferred from that of the well-characterized pig enzyme (Yokota et al. 1994).

Literature References
PubMed ID Title Journal Year
8083224 cDNA cloning and chromosome mapping of human dihydropyrimidine dehydrogenase, an enzyme associated with 5-fluorouracil toxicity and congenital thymine uraciluria

McBride, OW, Schnackerz, KD, Podschun, B, Lin, K, Gonzalez, FJ, Fernandez-Salguero, P, Yokota, H, Furuya, H

J Biol Chem 1994
Participants
Participates
Catalyst Activity

dihydropyrimidine dehydrogenase (NADP+) activity of DPYD dimer [cytosol]

Orthologous Events
Cross References
Rhea
Created
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