uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+

Stable Identifier
R-HSA-73585
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
reduction of uracil to form dihydrouracil
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uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+
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Cytosolic dihydropyrimidine dehydrogenase catalyzes the reaction of uracil and NADPH + H+ to form 5,6-dihydrouracil and NADP+. The mechanism of the human reaction is inferred from that of the well-characterized pig enzyme (Yokota et al. 1994).

Literature References
PubMed ID Title Journal Year
8083224 cDNA cloning and chromosome mapping of human dihydropyrimidine dehydrogenase, an enzyme associated with 5-fluorouracil toxicity and congenital thymine uraciluria

Yokota, H, Fernandez-Salguero, P, Furuya, H, Lin, K, McBride, OW, Podschun, B, Schnackerz, KD, Gonzalez, FJ

J Biol Chem 1994
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
dihydropyrimidine dehydrogenase (NADP+) activity of DPYD dimer [cytosol]
Physical Entity
DPYD dimer [cytosol]
Activity
dihydropyrimidine dehydrogenase (NADP+) activity (0017113)
Orthologous Events
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Caenorhabditis elegans)
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Canis familiaris)
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Danio rerio)
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Dictyostelium discoideum)
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Drosophila melanogaster)
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Gallus gallus)
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Mus musculus)
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Rattus norvegicus)
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Xenopus tropicalis)
Cross References
Rhea
Created
Jassal, B  (2003-06-17)