Cytosolic dihydropyrimidine dehydrogenase catalyzes the reaction of uracil and NADPH + H+ to form 5,6-dihydrouracil and NADP+. The mechanism of the human reaction is inferred from that of the well-characterized pig enzyme (Yokota et al. 1994).
McBride, OW, Schnackerz, KD, Podschun, B, Lin, K, Gonzalez, FJ, Fernandez-Salguero, P, Yokota, H, Furuya, H
dihydropyrimidine dehydrogenase (NADP+) activity of DPYD dimer [cytosol]
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