Reactome | reduction of uracil to form dihydrouracil

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reduction of uracil to form dihydrouracil Show undefined attributes

catalystActivity	[CatalystActivity:10832943] dihydropyrimidine dehydrogenase (NADP+) activity of DPYD dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10832945
displayName	reduction of uracil to form dihydrouracil
eventOf	[Pathway:R-DME-73621] Pyrimidine catabolism - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-73589] conversion of 5,6-dihydrouracil to 3-ureidopropionate - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-73585] reduction of uracil to form dihydrouracil - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-83962] Ura [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	reduction of uracil to form dihydrouracil uracil + NADPH + H(+) => 5,6-dihydrouracil + NADP(+)
output	[SimpleEntity:R-ALL-73584] 5,6-Dihydrouracil [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-73585
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-73621] Pyrimidine catabolism
(precedingEvent)	[Reaction:R-DME-73589] conversion of 5,6-dihydrouracil to 3-ureidopropionate
(inferredTo)	[Reaction:R-HSA-73585] reduction of uracil to form dihydrouracil

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