Reactome | uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+

Schema > Reaction > Entries

uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ Show undefined attributes

catalystActivity	[CatalystActivity:10429615] dihydropyrimidine dehydrogenase (NADP+) activity of DPYD dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10427439] Wright, Adam, 2024-03-07
dbId	10429617
displayName	uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+
eventOf	[Pathway:R-DRE-73621] Pyrimidine catabolism - Danio rerio
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-73589] 5,6-dihydrouracil + H2O => beta-ureidopropionate - Danio rerio
inferredFrom	[Reaction:R-HSA-73585] uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-83962] Ura [cytosol]
isInDisease	false
isInferred	true
name	uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ reduction of uracil to form dihydrouracil
output	[SimpleEntity:R-ALL-73584] 5,6-Dihydrouracil [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-73585
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-73621] Pyrimidine catabolism
(precedingEvent)	[Reaction:R-DRE-73589] 5,6-dihydrouracil + H2O => beta-ureidopropionate
(inferredTo)	[Reaction:R-HSA-73585] uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+

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