Reactome | (S)-dihydroorotate + ubiquinone => orotate + ubiquinol

Schema > Reaction > Entries

(S)-dihydroorotate + ubiquinone => orotate + ubiquinol Show undefined attributes

authored	[InstanceEdit:419450] D'Eustachio, P, 2009-05-01 14:10:50
catalystActivity	[CatalystActivity:419459] dihydroorotate dehydrogenase activity of DHODH holoenzyme [mitochondrial inner membrane]
category	transition
compartment	[Compartment:70616] mitochondrial inner membrane [Compartment:70101] cytosol
created	[InstanceEdit:419463] D'Eustachio, P, 2009-05-01 14:29:27
dbId	419452
displayName	(S)-dihydroorotate + ubiquinone => orotate + ubiquinol
edited	[InstanceEdit:419450] D'Eustachio, P, 2009-05-01 14:10:50
eventOf	[Pathway:R-GGA-419469] Pyrimidine metabolism: de novo synthesis of UMP - Gallus gallus
followingEvent	[Reaction:R-GGA-419462] orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate - Gallus gallus
inferredFrom	[Reaction:R-HSA-73569] DHODH:FMN oxidises (S)-DHO to orotate - Homo sapiens
input	[SimpleEntity:R-ALL-76630] (S)-DHO [cytosol] [SimpleEntity:R-ALL-73663] CoQ [mitochondrial inner membrane]
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	(S)-dihydroorotate + ubiquinone => orotate + ubiquinol
output	[SimpleEntity:R-ALL-76632] ORO [cytosol] [SimpleEntity:R-ALL-76633] QH2 [mitochondrial inner membrane]
precedingEvent	[Reaction:R-GGA-419465] N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O - Gallus gallus
releaseDate	2009-04-01
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-419452
summation	[Summation:419455] Dihydroorotate dehydrogenase catalyzes the oxidation of dihy...

Referrals

(hasEvent)	[Pathway:R-GGA-419469] Pyrimidine metabolism: de novo synthesis of UMP
(precedingEvent)	[Reaction:R-GGA-419462] orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate
(inferredTo)	[Reaction:R-HSA-73569] DHODH:FMN oxidises (S)-DHO to orotate

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