Reactome | DHODH:FMN oxidises (S)-DHO to orotate

Schema > Reaction > Entries

DHODH:FMN oxidises (S)-DHO to orotate Show undefined attributes

catalystActivity	[CatalystActivity:10563147] dihydroorotate dehydrogenase activity of DHODH:FMN [mitochondrial inner membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10563149
displayName	DHODH:FMN oxidises (S)-DHO to orotate
eventOf	[Pathway:R-DRE-500753] Pyrimidine biosynthesis - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-73567] UMPS dimer transfers phosphoribosyl group to ORO to form OMP - Danio rerio
inferredFrom	[Reaction:R-HSA-73569] DHODH:FMN oxidises (S)-DHO to orotate - Homo sapiens
input	[SimpleEntity:R-ALL-76630] (S)-DHO [cytosol] [SimpleEntity:R-ALL-73663] CoQ [mitochondrial inner membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	DHODH:FMN oxidises (S)-DHO to orotate S)-dihydroorotate + a ubiquinone => orotate + a ubiquinol (S)-dihydroorotate + ubiquinone => orotate + ubiquinol oxidation of (S)-Dihydroorotate to form Orotate
output	[SimpleEntity:R-ALL-76632] ORO [cytosol] [SimpleEntity:R-ALL-76633] QH2 [mitochondrial inner membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-73569
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-500753] Pyrimidine biosynthesis
(precedingEvent)	[Reaction:R-DRE-73567] UMPS dimer transfers phosphoribosyl group to ORO to form OMP
(inferredTo)	[Reaction:R-HSA-73569] DHODH:FMN oxidises (S)-DHO to orotate

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