Reactome | (d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1)

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(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) Show undefined attributes

catalystActivity	[CatalystActivity:73495] nucleoside monophosphate kinase activity of CMPK1, AK1 [cytosol]
catalystActivityReference	[CatalystActivityReference:9643747] nucleoside monophosphate kinase activity of CMPK1, AK1 [cytosol] Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates.
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:73446] Jassal, B, 2003-06-17 09:00:25
crossReference	[DatabaseIdentifier:12668062] RHEA:24401 [DatabaseIdentifier:9975774] RHEA:25095 [DatabaseIdentifier:9975769] RHEA:11601 [DatabaseIdentifier:9975908] RHEA:24401
dbId	73548
deleted	[Deleted:500010] Deletion of instances: 73627, 73623 [Deleted:500015] Deletion of instance: 110107
displayName	(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1)
eventOf	[Pathway:R-HSA-499943] Interconversion of nucleotide di- and triphosphates - Homo sapiens
followingEvent	[Reaction:R-HSA-482619] (d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) - Homo sapiens
input	[DefinedSet:R-ALL-500009] (d)CMP, UMP [cytosol] [SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:74569] Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates. [LiteratureReference:110112] Kinetics and equilibria of pyrimidine nucleoside monophosphate kinase from human erythrocytes
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) dCMP + ATP => dCDP + ADP CMP + ATP => CDP + ADP UMP + ATP => UDP + ADP
orthologousEvent	[Reaction:R-PFA-73548] (d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) - Plasmodium falciparum [Reaction:R-SCE-73548] (d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) - Saccharomyces cerevisiae [Reaction:R-SPO-73548] (d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) - Schizosaccharomyces pombe [Reaction:R-DDI-73548] (d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) - Dictyostelium discoideum [Reaction:R-CEL-73548] (d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) - Caenorhabditis elegans [Reaction:R-DME-73548] (d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) - Drosophila melanogaster [Reaction:R-GGA-73548] (d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) - Gallus gallus [Reaction:R-XTR-73548] (d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) - Xenopus tropicalis [Reaction:R-DRE-73548] (d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) - Danio rerio [Reaction:R-SSC-73548] (d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) - Sus scrofa [Reaction:R-BTA-73548] (d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) - Bos taurus [Reaction:R-CFA-73548] (d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) - Canis familiaris [Reaction:R-RNO-73548] (d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) - Rattus norvegicus [Reaction:R-MMU-73548] (d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) - Mus musculus
output	[DefinedSet:R-ALL-500006] (d)CDP, UDP [cytosol] [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-HSA-73598] (2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) - Homo sapiens [Reaction:R-HSA-73564] UMPS dimer decarboxylates OMP to UMP - Homo sapiens [Reaction:R-HSA-73599] cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] - Homo sapiens
releaseDate	2004-07-06
reverseReaction	[Reaction:R-HSA-75125] (d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1)
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-73548
summation	[Summation:499938] Cytosolic UMP-CMP kinase (CMPK1) catalyzes the reversible re...
updateTrackers	[UpdateTracker:9791039] Update Tracker - [Reaction:73548] (d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) - v32:[add_removeInput, add_removeOutput, add_removeSummation]

Referrals

(updatedInstance)	[UpdateTracker:9791039] Update Tracker - [Reaction:73548] (d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) - v32:[add_removeInput, add_removeOutput, add_removeSummation]
(replacementInstances)	[Deleted:500015] Deletion of instance: 110107 [Deleted:500010] Deletion of instances: 73627, 73623
(hasEvent)	[Pathway:R-HSA-499943] Interconversion of nucleotide di- and triphosphates
(precedingEvent)	[Reaction:R-HSA-482619] (d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3)

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