Reactome | UMPS dimer decarboxylates OMP to UMP

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UMPS dimer decarboxylates OMP to UMP Show undefined attributes

catalystActivity	[CatalystActivity:10735204] orotidine-5'-phosphate decarboxylase activity of UMPS dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10735206
displayName	UMPS dimer decarboxylates OMP to UMP
eventOf	[Pathway:R-GGA-500753] Pyrimidine biosynthesis - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-73548] (d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) - Gallus gallus
inferredFrom	[Reaction:R-HSA-73564] UMPS dimer decarboxylates OMP to UMP - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-111629] OMP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	UMPS dimer decarboxylates OMP to UMP orotidine 5'-phosphate + H(+) => UMP + CO2 orotidine 5'-monophosphate => uridine 5'-monophosphate + CO2 decarboxylation of Orotidine 5'-phosphate to form Uridine 5'-phosphate
output	[SimpleEntity:R-ALL-113528] CO2 [cytosol] [SimpleEntity:R-ALL-109402] UMP [cytosol]
precedingEvent	[Reaction:R-GGA-73567] UMPS dimer transfers phosphoribosyl group to ORO to form OMP - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-73564
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-GGA-73548] (d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1)
(hasEvent)	[Pathway:R-GGA-500753] Pyrimidine biosynthesis
(inferredTo)	[Reaction:R-HSA-73564] UMPS dimer decarboxylates OMP to UMP

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