(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1)

Stable Identifier
R-HSA-73548
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1)
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Cytosolic UMP-CMP kinase (CMPK1) catalyzes the reversible reaction of CMP, dCMP, or UMP and ATP to form CDP, dCDP, or UDP and ADP (Liou et al. 2002; Scott and Wright 1979).

Literature References
PubMed ID Title Journal Year
11912132 Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates.

Lam, W, Cheng, YC, Jiang, Z, Liou, JY, Dutschman, GE

Cancer Res 2002
40615 Kinetics and equilibria of pyrimidine nucleoside monophosphate kinase from human erythrocytes

Wright, RC, Scott, EM

Biochim Biophys Acta 1979
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Event Information
Reverse Reaction
(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Homo sapiens)
Catalyst Activity

nucleoside monophosphate kinase activity of CMPK1, AK1 [cytosol]

Physical Entity
CMPK1, AK1 [cytosol] (Homo sapiens)
Activity
nucleoside monophosphate kinase activity (GO:0050145)
Orthologous Events
(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Bos taurus)
(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Caenorhabditis elegans)
(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Canis familiaris)
(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Danio rerio)
(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Dictyostelium discoideum)
(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Drosophila melanogaster)
(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Gallus gallus)
(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Mus musculus)
(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Plasmodium falciparum)
(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Rattus norvegicus)
(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Saccharomyces cerevisiae)
(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Schizosaccharomyces pombe)
(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Sus scrofa)
(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Xenopus tropicalis)
Cross References
Rhea
Created
Jassal, B  (2003-06-17)
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