Reactome | cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]

Schema > Reaction > Entries

cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] Show undefined attributes

catalystActivity	[CatalystActivity:73505] nucleoside kinase activity of UCK1 tetramer [cytosol]
catalystActivityReference	[CatalystActivityReference:9644069] nucleoside kinase activity of UCK1 tetramer [cytosol] Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:73446] Jassal, B, 2003-06-17 09:00:25
crossReference	[DatabaseIdentifier:9976243] RHEA:24675 [DatabaseIdentifier:9976249] RHEA:16826
dbId	73599
deleted	[Deleted:500763] Deletion of instances: 109883, 73550
displayName	cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]
eventOf	[Pathway:R-HSA-73614] Pyrimidine salvage - Homo sapiens
followingEvent	[Reaction:R-HSA-73548] (d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [DefinedSet:R-ALL-500759] Cyt-Rib, Ura-Rib [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:109887] Uridine kinase activities and pyrimidine nucleoside phosphorylation in fluoropyrimidine-sensitive and -resistant cell lines of the Novikoff hepatoma [LiteratureReference:109895] Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] cytidine + ATP => CMP + ADP + H(+) uridine + ATP => UMP + ADP + H(+)
orthologousEvent	[Reaction:R-MMU-73599] cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] - Mus musculus [Reaction:R-DDI-73599] cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] - Dictyostelium discoideum [Reaction:R-CEL-73599] cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] - Caenorhabditis elegans [Reaction:R-DME-73599] cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] - Drosophila melanogaster [Reaction:R-GGA-73599] cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] - Gallus gallus [Reaction:R-XTR-73599] cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] - Xenopus tropicalis [Reaction:R-DRE-73599] cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] - Danio rerio [Reaction:R-SSC-73599] cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] - Sus scrofa [Reaction:R-BTA-73599] cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] - Bos taurus [Reaction:R-CFA-73599] cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] - Canis familiaris [Reaction:R-RNO-73599] cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] - Rattus norvegicus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [DefinedSet:R-ALL-500761] CMP, UMP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2004-07-06
releaseStatus	UPDATED
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9977064] D'Eustachio, Peter, 2025-12-16
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-73599
summation	[Summation:179297] Cytosolic uridine-cytidine kinase 1 (UCK1) catalyzes the rea...
updateTrackers	[UpdateTracker:9791149] Update Tracker - [Reaction:73599] cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] - v32:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText] [UpdateTracker:9984741] Update Tracker - [Reaction:73599] cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] - v96:[removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9791149] Update Tracker - [Reaction:73599] cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] - v32:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText] [UpdateTracker:9984741] Update Tracker - [Reaction:73599] cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] - v96:[removeOutput]
(replacementInstances)	[Deleted:500763] Deletion of instances: 109883, 73550
(precedingEvent)	[Reaction:R-HSA-73548] (d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1)
(hasEvent)	[Pathway:R-HSA-73614] Pyrimidine salvage