Reactome | ST3GAL5 transfers NeuNAc to ceramides

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ST3GAL5 transfers NeuNAc to ceramides Show undefined attributes

authored	[InstanceEdit:9844761] Stephan, Ralf, 2023-09-22
catalystActivity	[CatalystActivity:9844856] beta-galactoside (CMP) alpha-2,3-sialyltransferase activity of ST3GAL5 [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane [Compartment:17963] Golgi lumen
created	[InstanceEdit:9844880] Stephan, Ralf, 2023-09-23
crossReference	[DatabaseIdentifier:12667873] RHEA:41776
dbId	9844860
displayName	ST3GAL5 transfers NeuNAc to ceramides
edited	[InstanceEdit:9851336] Stephan, Ralf, 2023-10-23
eventOf	[Pathway:R-HSA-9840309] Glycosphingolipid biosynthesis - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9850731] Vesicles transport GSL from Golgi to plasma membrane - Homo sapiens
input	[SimpleEntity:R-ALL-727815] CMP-Neu5Ac [Golgi lumen] [DefinedSet:R-ALL-9844855] LacCer/GalCer/GA1/GA2 [Golgi membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:4086330] Expression cloning and functional characterization of human cDNA for ganglioside GM3 synthase [LiteratureReference:6785916] Ceramide glycosylation catalyzed by glucosylceramide synthase and cancer drug resistance [LiteratureReference:9844869] Human GM3 synthase: a new mRNA variant encodes an NH2-terminal extended form of the protein [LiteratureReference:9844872] Evidence supporting a late Golgi location for lactosylceramide to ganglioside GM3 conversion [LiteratureReference:9844854] Molecular identification, tissue distribution and subcellular localization of mST3GalV/GM3 synthase [LiteratureReference:9844875] Ganglioside GM3 Synthase Deficiency in Mouse Models and Human Patients [LiteratureReference:9844866] Mass spectrometric quantification of plasma glycosphingolipids in human GM3 ganglioside deficiency
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	ST3GAL5 transfers NeuNAc to ceramides
orthologousEvent	[Reaction:R-GGA-9844860] ST3GAL5 transfers NeuNAc to ceramides - Gallus gallus [Reaction:R-DRE-9844860] ST3GAL5 transfers NeuNAc to ceramides - Danio rerio [Reaction:R-SSC-9844860] ST3GAL5 transfers NeuNAc to ceramides - Sus scrofa [Reaction:R-BTA-9844860] ST3GAL5 transfers NeuNAc to ceramides - Bos taurus [Reaction:R-CFA-9844860] ST3GAL5 transfers NeuNAc to ceramides - Canis familiaris [Reaction:R-RNO-9844860] ST3GAL5 transfers NeuNAc to ceramides - Rattus norvegicus [Reaction:R-MMU-9844860] ST3GAL5 transfers NeuNAc to ceramides - Mus musculus
output	[SimpleEntity:R-ALL-727810] CMP [Golgi lumen] [DefinedSet:R-ALL-9844871] GM1/2/3/4 [Golgi membrane] [SimpleEntity:R-ALL-425969] H+ [Golgi lumen]
precedingEvent	[Reaction:R-HSA-6785933] UGT8 transfers Gal from UDP-Gal to CERA - Homo sapiens [Reaction:R-HSA-727807] SLC35A1 exchanges CMP-Neu5Ac for CMP - Homo sapiens
releaseDate	2023-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9851344] D'Eustachio, Peter, 2023-10-24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9844860
summation	[Summation:9844861] Following its biosynthesis, a fraction of GalCer reaches the...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-9850731] Vesicles transport GSL from Golgi to plasma membrane
(hasEvent)	[Pathway:R-HSA-9840309] Glycosphingolipid biosynthesis

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