Reactome | The 60S subunit joins the translation initiation complex

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The 60S subunit joins the translation initiation complex Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:72607] Merrick, WC, 2002-12-16 00:00:00
dbId	72672
displayName	The 60S subunit joins the translation initiation complex
eventOf	[Pathway:R-HSA-72706] GTP hydrolysis and joining of the 60S ribosomal subunit - Homo sapiens
followingEvent	[Reaction:R-HSA-72671] eIF5B:GTP is hydrolyzed and released - Homo sapiens
input	[Complex:R-HSA-72508] 40S:Met-tRNAi:mRNA [cytosol] [Complex:R-HSA-72499] 60S ribosomal complex [cytosol] [Complex:R-HSA-72503] eIF5B:GTP [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:72721] Initiation of mammalian protein synthesis. I. Purification and characterization of seven initiation factors [LiteratureReference:72719] Purification and characterization of homogeneous initiation factor M2A from rabbit reticulocytes [LiteratureReference:72715] The joining of ribosomal subunits in eukaryotes requires eIF5B
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	The 60S subunit joins the translation initiation complex
orthologousEvent	[Reaction:R-RNO-72672] The 60S subunit joins the translation initiation complex - Rattus norvegicus [Reaction:R-PFA-72672] The 60S subunit joins the translation initiation complex - Plasmodium falciparum [Reaction:R-SCE-72672] The 60S subunit joins the translation initiation complex - Saccharomyces cerevisiae [Reaction:R-SPO-72672] The 60S subunit joins the translation initiation complex - Schizosaccharomyces pombe [Reaction:R-DDI-72672] The 60S subunit joins the translation initiation complex - Dictyostelium discoideum [Reaction:R-CEL-72672] The 60S subunit joins the translation initiation complex - Caenorhabditis elegans [Reaction:R-DME-72672] The 60S subunit joins the translation initiation complex - Drosophila melanogaster [Reaction:R-XTR-72672] The 60S subunit joins the translation initiation complex - Xenopus tropicalis [Reaction:R-SSC-72672] The 60S subunit joins the translation initiation complex - Sus scrofa [Reaction:R-BTA-72672] The 60S subunit joins the translation initiation complex - Bos taurus [Reaction:R-CFA-72672] The 60S subunit joins the translation initiation complex - Canis familiaris [Reaction:R-MMU-72672] The 60S subunit joins the translation initiation complex - Mus musculus
output	[Complex:R-HSA-72504] 80S:Met-tRNAi:mRNA:eIF5B:GTP [cytosol]
precedingEvent	[Reaction:R-HSA-72673] Release of 40S and 60S subunits from the 80S ribosome - Homo sapiens [Reaction:R-HSA-72619] eIF2:GTP is hydrolyzed, eIFs are released - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-72672
summation	[Summation:72739] Joining of the 60S subunit to form the 80S ribosome is catal...

Referrals

(hasEvent)	[Pathway:R-HSA-72706] GTP hydrolysis and joining of the 60S ribosomal subunit
(precedingEvent)	[Reaction:R-HSA-72671] eIF5B:GTP is hydrolyzed and released

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