Reactome | The 60S subunit joins the translation initiation complex

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The 60S subunit joins the translation initiation complex Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10336439
displayName	The 60S subunit joins the translation initiation complex
eventOf	[Pathway:R-BTA-72706] GTP hydrolysis and joining of the 60S ribosomal subunit - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-72671] eIF5B:GTP is hydrolyzed and released - Bos taurus
inferredFrom	[Reaction:R-HSA-72672] The 60S subunit joins the translation initiation complex - Homo sapiens
input	[Complex:R-BTA-72508] 40S:Met-tRNAi:mRNA [cytosol] [Complex:R-BTA-72499] 60S ribosomal complex [cytosol] [Complex:R-BTA-72503] eIF5B:GTP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	The 60S subunit joins the translation initiation complex
output	[Complex:R-BTA-72504] 80S:Met-tRNAi:mRNA:eIF5B:GTP [cytosol]
precedingEvent	[Reaction:R-BTA-72673] Release of 40S and 60S subunits from the 80S ribosome - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-72672
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-72706] GTP hydrolysis and joining of the 60S ribosomal subunit
(precedingEvent)	[Reaction:R-BTA-72671] eIF5B:GTP is hydrolyzed and released
(inferredTo)	[Reaction:R-HSA-72672] The 60S subunit joins the translation initiation complex

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