The 60S subunit joins the translation initiation complex

Stable Identifier
R-HSA-72672
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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The 60S subunit joins the translation initiation complex
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Joining of the 60S subunit to form the 80S ribosome is catalyzed by the presence of GTP-bound eIF5B.
Literature References
PubMed ID Title Journal Year
1095581 Purification and characterization of homogeneous initiation factor M2A from rabbit reticulocytes.

Merrick, WC, Kemper, WM, Anderson, WF

J Biol Chem 1975
10659855 The joining of ribosomal subunits in eukaryotes requires eIF5B.

Pestova, TV, Lomakin, IB, Lee, JH, Choi, SK, Dever, TE, Hellen, CU

Nature 2000
592398 Initiation of mammalian protein synthesis. I. Purification and characterization of seven initiation factors.

Schreier, MH, Erni, B, Staehelin, T

J Mol Biol 1978
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Orthologous Events
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The 60S subunit joins the translation initiation complex (Mus musculus)
The 60S subunit joins the translation initiation complex (Plasmodium falciparum)
The 60S subunit joins the translation initiation complex (Rattus norvegicus)
The 60S subunit joins the translation initiation complex (Saccharomyces cerevisiae)
The 60S subunit joins the translation initiation complex (Schizosaccharomyces pombe)
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The 60S subunit joins the translation initiation complex (Xenopus tropicalis)
Created
Merrick, WC  (2002-12-16)
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