Reactome | GTP hydrolysis and joining of the 60S ribosomal subunit

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GTP hydrolysis and joining of the 60S ribosomal subunit Show undefined attributes

created	[InstanceEdit:72607] Merrick, WC, 2002-12-16 00:00:00
crossReference	[DatabaseIdentifier:12819455] BioModels Database:BIOMD0000000293
dbId	72706
displayName	GTP hydrolysis and joining of the 60S ribosomal subunit
eventOf	[Pathway:R-HSA-72737] Cap-dependent Translation Initiation - Homo sapiens
followingEvent	[Pathway:R-HSA-72731] Recycling of eIF2:GDP - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-72619] eIF2:GTP is hydrolyzed, eIFs are released - Homo sapiens [Reaction:R-HSA-72671] eIF5B:GTP is hydrolyzed and released - Homo sapiens [Reaction:R-HSA-72672] The 60S subunit joins the translation initiation complex - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2011-09-30
literatureReference	[LiteratureReference:72708] A multifactor complex of eukaryotic initiation factors, eIF1, eIF2, eIF3, eIF5, and initiator tRNA(Met) is an important translation initiation intermediate in vivo [LiteratureReference:72677] Binding and release of radiolabeled eukaryotic initiation factors 2 and 3 during 80 S initiation complex formation [LiteratureReference:72713] Function of eukaryotic initiation factor 5 in the formation of an 80 S ribosomal polypeptide chain initiation complex [LiteratureReference:72721] Initiation of mammalian protein synthesis. I. Purification and characterization of seven initiation factors [LiteratureReference:72652] Initiation of mammalian protein synthesis. II. The assembly of the initiation complex with purified initiation factors [LiteratureReference:72719] Purification and characterization of homogeneous initiation factor M2A from rabbit reticulocytes [LiteratureReference:72715] The joining of ribosomal subunits in eukaryotes requires eIF5B [LiteratureReference:72650] The mechanism of action of protein synthesis initiation factors from rabbit reticulocytes
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	GTP hydrolysis and joining of the 60S ribosomal subunit
orthologousEvent	[Pathway:R-RNO-72706] GTP hydrolysis and joining of the 60S ribosomal subunit - Rattus norvegicus [Pathway:R-PFA-72706] GTP hydrolysis and joining of the 60S ribosomal subunit - Plasmodium falciparum [Pathway:R-SCE-72706] GTP hydrolysis and joining of the 60S ribosomal subunit - Saccharomyces cerevisiae [Pathway:R-SPO-72706] GTP hydrolysis and joining of the 60S ribosomal subunit - Schizosaccharomyces pombe [Pathway:R-DDI-72706] GTP hydrolysis and joining of the 60S ribosomal subunit - Dictyostelium discoideum [Pathway:R-CEL-72706] GTP hydrolysis and joining of the 60S ribosomal subunit - Caenorhabditis elegans [Pathway:R-DME-72706] GTP hydrolysis and joining of the 60S ribosomal subunit - Drosophila melanogaster [Pathway:R-GGA-72706] GTP hydrolysis and joining of the 60S ribosomal subunit - Gallus gallus [Pathway:R-XTR-72706] GTP hydrolysis and joining of the 60S ribosomal subunit - Xenopus tropicalis [Pathway:R-SSC-72706] GTP hydrolysis and joining of the 60S ribosomal subunit - Sus scrofa [Pathway:R-BTA-72706] GTP hydrolysis and joining of the 60S ribosomal subunit - Bos taurus [Pathway:R-CFA-72706] GTP hydrolysis and joining of the 60S ribosomal subunit - Canis familiaris [Pathway:R-MMU-72706] GTP hydrolysis and joining of the 60S ribosomal subunit - Mus musculus
precedingEvent	[Pathway:R-HSA-72702] Ribosomal scanning and start codon recognition - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-72706
summation	[Summation:72707] Hydrolysis of eIF2-GTP occurs after the Met-tRNAi has recogn...
updateTrackers	[UpdateTracker:9789188] Update Tracker - [Pathway:72706] GTP hydrolysis and joining of the 60S ribosomal subunit - v38:[addLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9789188] Update Tracker - [Pathway:72706] GTP hydrolysis and joining of the 60S ribosomal subunit - v38:[addLiteratureReference]
(hasEvent)	[Pathway:R-HSA-72737] Cap-dependent Translation Initiation
(precedingEvent)	[Pathway:R-HSA-72731] Recycling of eIF2:GDP

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