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EIF2S1:EIF2S2:EIF2S3 [cytosol]
Stable Identifier
R-HSA-72515
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Synonyms
eIF2 subunit complex, MP
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to mitochondrial stress (Homo sapiens)
DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha) (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
Cellular response to starvation (Homo sapiens)
Response of EIF2AK4 (GCN2) to amino acid deficiency (Homo sapiens)
p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
Response of EIF2AK1 (HRI) to heme deficiency (Homo sapiens)
p-T,T486,T488-EIF2AK1 phosphorylates EIF2S1 (eIF2-alpha) (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
Unfolded Protein Response (UPR) (Homo sapiens)
PERK regulates gene expression (Homo sapiens)
EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
PKR-mediated signaling (Homo sapiens)
p-PKR dimer phosphorylates eIF2-alpha (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Initiation (Homo sapiens)
Cap-dependent Translation Initiation (Homo sapiens)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Homo sapiens)
Translation initiation complex formation (Homo sapiens)
Formation of translation initiation complexes containing mRNA that does not circularize (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
Formation of the ternary complex, and subsequently, the 43S complex (Homo sapiens)
De novo formation of eIF2:GTP (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
Formation of the 43S pre-initiation complex (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
Met-tRNAi binds to eIF2:GTP to form the ternary complex (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
GTP hydrolysis and joining of the 60S ribosomal subunit (Homo sapiens)
eIF2:GTP is hydrolyzed, eIFs are released (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
eIF2:GDP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
Recycling of eIF2:GDP (Homo sapiens)
Formation of eIF2:GDP:eIF2B intermediate (Homo sapiens)
eIF2:GDP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
eIF2:GDP: eIF2B [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
eIF2 activation (Homo sapiens)
eIF2:GDP: eIF2B [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
Ribosomal scanning and start codon recognition (Homo sapiens)
Ribosomal scanning (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
Start codon recognition (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
L13a-mediated translational silencing of Ceruloplasmin expression (Homo sapiens)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
Transport of small molecules (Homo sapiens)
ABC-family proteins mediated transport (Homo sapiens)
ABCF1 binds EIF2 (Homo sapiens)
ABCF1:EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
Participants
components
EIF2S1 [cytosol]
(Homo sapiens)
EIF2S2 [cytosol]
(Homo sapiens)
EIF2S3 [cytosol]
(Homo sapiens)
Participates
as a component of
ABCF1:EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
eIF2:GDP: eIF2B [cytosol] (Homo sapiens)
eIF2:GDP [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
as an input of
ABCF1 binds EIF2 (Homo sapiens)
p-T,T486,T488-EIF2AK1 phosphorylates EIF2S1 (eIF2-alpha) (Homo sapiens)
EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Homo sapiens)
p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)
DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha) (Homo sapiens)
De novo formation of eIF2:GTP (Homo sapiens)
Start codon recognition (Homo sapiens)
p-PKR dimer phosphorylates eIF2-alpha (Homo sapiens)
as an output of
Start codon recognition (Homo sapiens)
Inferred To
EIF2S1:EIF2S2:EIF2S3 [cytosol]
(Bos taurus)
EIF2S1:EIF2S2:EIF2S3 [cytosol]
(Caenorhabditis elegans)
EIF2S1:EIF2S2:EIF2S3 [cytosol]
(Canis familiaris)
EIF2S1:EIF2S2:EIF2S3 [cytosol]
(Danio rerio)
EIF2S1:EIF2S2:EIF2S3 [cytosol]
(Dictyostelium discoideum)
EIF2S1:EIF2S2:EIF2S3 [cytosol]
(Drosophila melanogaster)
EIF2S1:EIF2S2:EIF2S3 [cytosol]
(Gallus gallus)
EIF2S1:EIF2S2:EIF2S3 [cytosol]
(Mus musculus)
EIF2S1:EIF2S2:EIF2S3 [cytosol]
(Plasmodium falciparum)
EIF2S1:EIF2S2:EIF2S3 [cytosol]
(Rattus norvegicus)
EIF2S1:EIF2S2:EIF2S3 [cytosol]
(Saccharomyces cerevisiae)
EIF2S1:EIF2S2:EIF2S3 [cytosol]
(Schizosaccharomyces pombe)
EIF2S1:EIF2S2:EIF2S3 [cytosol]
(Sus scrofa)
EIF2S1:EIF2S2:EIF2S3 [cytosol]
(Xenopus tropicalis)
Cross References
ComplexPortal
CPX-2716
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